The NADase-negative variant of the Streptococcus pyogenes toxin NAD⁺ glycohydrolase induces JNK1-mediated programmed cellular necrosis

Keyphrases

• Streptococcus Pyogenes (S. pyogenes) 100%
• NAD Glycohydrolase 100%
• Cell Necrosis 100%
• JNK1 100%
• NADase 100%
• Streptolysin O 31%
• Necrosis 21%
• Host Cell 15%
• Mitogen-activated Protein Kinase 10%
• Infected Cells 10%
• Cell Death 10%
• Translocated 10%
• Signaling Molecules 10%
• Epithelial Cells 10%
• Metabolic 10%
• Programmed Necrosis 10%
• NADase Activity 10%
• Disease Pattern 5%
• Virulence Factors 5%
• Cell Membrane 5%
• Depolarization 5%
• RNA Interference 5%
• Immune System 5%
• Human Pathogens 5%
• NF-B 5%
• Nicotinamide Adenine Dinucleotide (NAD+) 5%
• Suicide 5%
• Distinct Mechanism 5%
• Activation Patterns 5%
• Bacterial Pathogens 5%
• Mitochondria-associated Membranes 5%
• HeLa 5%
• Cell-Associated 5%
• JNK Pathway 5%
• Membrane Activation 5%
• Natural Variants 5%
• Cellular Energy 5%
• Inflammatory Profile 5%
• Synergistic Mechanism 5%
• Natural Form 5%
• Cytosol 5%
• Dying Cell 5%
• Reactive Oxygen Species Generation 5%
• Host Signaling 5%

Immunology and Microbiology

• Streptococcus pyogenes 100%
• Glycoside Hydrolase 100%
• Streptolysin 31%
• Host Cell 21%
• Cell Death 10%
• Mitogen 10%
• Virulence Factor 5%
• Infectious Agent 5%
• Cytosol 5%
• Signal Transduction 5%
• Cell Membrane 5%
• Infectious Disease 5%
• Human Pathogen 5%
• Cell Energy 5%
• Immune System 5%
• RNAI 5%
• Programmed Cell Death 5%
• Infection 5%
• Dioxygen 5%