The myocardial and coronary histopathology and pathogenesis of hypoplastic left heart syndrome

Charles R. Cole, Pirooz Eghtesady

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Hypoplastic left heart syndrome has the greatest mortality rate among all CHDs and without palliation is uniformly fatal. Despite noble efforts, the aetiology of this syndrome is unknown and a cure remains elusive. The genetic and anatomic heterogeneity of hypoplastic left heart syndrome supports a rethinking of old hypotheses and warrants further investigation into the histological and vascular variations recognised with this syndrome. In an effort to elucidate the pathogenesis of hypoplastic left heart syndrome, this review will focus on its unique myocardial and coronary pathology as well as evaluate the association of hypoplastic left heart syndrome with the endocardial fibroelastosis reaction.

Original languageEnglish
Pages (from-to)19-29
Number of pages11
JournalCardiology in the young
Volume26
Issue number1
DOIs
StatePublished - Dec 22 2014

Keywords

  • CHD
  • Hypoplastic left heart syndrome
  • coronary arteries
  • endocardial fibroelastosis
  • myocardial morphology

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