TY - JOUR
T1 - The murine diabetogenic class II histocompatibility molecule I-A g7
T2 - Structural and functional properties and specificity of peptide selection
AU - Suri, Anish
AU - Unanue, Emil R.
N1 - Funding Information:
We thank the National Institutes of Health and the Kilo Diabetes and Vascular Research Foundation for the support of our work cited here, and we acknowledge our colleagues who have participated in this work: Michael Gross and James Walters who were in charge of the mass spectrometry work; Daved Fremont and Robert Latek who were responsible for the structural analysis; and our laboratory colleagues Osami Kanagawa, Boris Calderon, Eugenio Carrasco‐Marin, Matteo Levisetti, and Shirley Petzold.
PY - 2005
Y1 - 2005
N2 - The onset of type 1 diabetes mellitus (T1DM) is directly linked to the expression of class II MHC molecules. The NOD mouse, which is an excellent animal model for the human disease, expresses the I-Ag7 molecule that shares many features with the human diabetogenic class II MHC alleles. In this review, the structural, biochemical, and biological properties of the I-A g7 molecules and how they relate to onset of diabetes is discussed. In particular, the focus is on the unique properties of peptide selection by I-Ag7 that reveal the preferred binding motif of diabetogenic MHC molecules and its role in display of peptides derived from islet β cells.
AB - The onset of type 1 diabetes mellitus (T1DM) is directly linked to the expression of class II MHC molecules. The NOD mouse, which is an excellent animal model for the human disease, expresses the I-Ag7 molecule that shares many features with the human diabetogenic class II MHC alleles. In this review, the structural, biochemical, and biological properties of the I-A g7 molecules and how they relate to onset of diabetes is discussed. In particular, the focus is on the unique properties of peptide selection by I-Ag7 that reveal the preferred binding motif of diabetogenic MHC molecules and its role in display of peptides derived from islet β cells.
UR - http://www.scopus.com/inward/record.url?scp=26444546932&partnerID=8YFLogxK
U2 - 10.1016/S0065-2776(05)88007-1
DO - 10.1016/S0065-2776(05)88007-1
M3 - Review article
C2 - 16227092
AN - SCOPUS:26444546932
SN - 0065-2776
VL - 88
SP - 235
EP - 265
JO - Advances in Immunology
JF - Advances in Immunology
ER -