TY - JOUR
T1 - The Multifaceted Role of Autophagy in Endometrium Homeostasis and Disease
AU - Popli, Pooja
AU - Sun, Ally J.
AU - Kommagani, Ramakrishna
N1 - Funding Information:
We thank Jennifer Brazill, Mandy Chan, and Anne Robinson for assisting with schematic figure preparation in association with InPrint, Washington University, St. Louis, MO. We also thank Anthony Bartley, Scientific Graphic Designer for Fig. 1 preparation, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO.
Funding Information:
This work was funded, in part, by the National Institutes of Health/National Institute of Child Health and Human Development grants R00HD080742, RO1HD065435 and R01HD102680 to RK and Washington University School of Medicine start-up funds to RK.
Publisher Copyright:
© 2021, Society for Reproductive Investigation.
PY - 2022/4
Y1 - 2022/4
N2 - Autophagy is a conserved fundamental cellular process with a primary function of catabolizing harmful or surplus cellular contents such as protein aggregates, dysfunctional/long-lived organelles, intracellular pathogens, and storage nutrients. An increasing body of evidence reveals that basal autophagy is essential for maintaining endometrial homeostasis and mediating endometrial-specific functions, including menstrual cycle, embryo implantation, and decidualization. However, perturbed levels of autophagy can lead to severe endometrial pathologies, including endometriosis, endometrial hyperplasia, endometrial cancer, adenomyosis, and leiomyoma. This review highlights the most recent findings on the activity, regulation, and function of autophagy in endometrium physiology and pathology. Understanding the mechanistic roles of autophagy in endometrium homeostasis and disease is key to developing novel therapeutic strategies for endometrium-related infertility and malignancies.
AB - Autophagy is a conserved fundamental cellular process with a primary function of catabolizing harmful or surplus cellular contents such as protein aggregates, dysfunctional/long-lived organelles, intracellular pathogens, and storage nutrients. An increasing body of evidence reveals that basal autophagy is essential for maintaining endometrial homeostasis and mediating endometrial-specific functions, including menstrual cycle, embryo implantation, and decidualization. However, perturbed levels of autophagy can lead to severe endometrial pathologies, including endometriosis, endometrial hyperplasia, endometrial cancer, adenomyosis, and leiomyoma. This review highlights the most recent findings on the activity, regulation, and function of autophagy in endometrium physiology and pathology. Understanding the mechanistic roles of autophagy in endometrium homeostasis and disease is key to developing novel therapeutic strategies for endometrium-related infertility and malignancies.
KW - Adenomyosis
KW - Autophagy
KW - Endometrial Cancer
KW - Endometrial Hyperplasia
KW - Endometriosis
KW - Endometrium
KW - Uterine Fibroids/Leiomyoma
UR - http://www.scopus.com/inward/record.url?scp=85104882865&partnerID=8YFLogxK
U2 - 10.1007/s43032-021-00587-2
DO - 10.1007/s43032-021-00587-2
M3 - Review article
C2 - 33877643
AN - SCOPUS:85104882865
VL - 29
SP - 1054
EP - 1067
JO - Reproductive Sciences
JF - Reproductive Sciences
SN - 1933-7191
IS - 4
ER -