TY - JOUR
T1 - The Multifaceted Role of Autophagy in Endometrium Homeostasis and Disease
AU - Popli, Pooja
AU - Sun, Ally J.
AU - Kommagani, Ramakrishna
N1 - Publisher Copyright:
© 2021, Society for Reproductive Investigation.
PY - 2022/4
Y1 - 2022/4
N2 - Autophagy is a conserved fundamental cellular process with a primary function of catabolizing harmful or surplus cellular contents such as protein aggregates, dysfunctional/long-lived organelles, intracellular pathogens, and storage nutrients. An increasing body of evidence reveals that basal autophagy is essential for maintaining endometrial homeostasis and mediating endometrial-specific functions, including menstrual cycle, embryo implantation, and decidualization. However, perturbed levels of autophagy can lead to severe endometrial pathologies, including endometriosis, endometrial hyperplasia, endometrial cancer, adenomyosis, and leiomyoma. This review highlights the most recent findings on the activity, regulation, and function of autophagy in endometrium physiology and pathology. Understanding the mechanistic roles of autophagy in endometrium homeostasis and disease is key to developing novel therapeutic strategies for endometrium-related infertility and malignancies.
AB - Autophagy is a conserved fundamental cellular process with a primary function of catabolizing harmful or surplus cellular contents such as protein aggregates, dysfunctional/long-lived organelles, intracellular pathogens, and storage nutrients. An increasing body of evidence reveals that basal autophagy is essential for maintaining endometrial homeostasis and mediating endometrial-specific functions, including menstrual cycle, embryo implantation, and decidualization. However, perturbed levels of autophagy can lead to severe endometrial pathologies, including endometriosis, endometrial hyperplasia, endometrial cancer, adenomyosis, and leiomyoma. This review highlights the most recent findings on the activity, regulation, and function of autophagy in endometrium physiology and pathology. Understanding the mechanistic roles of autophagy in endometrium homeostasis and disease is key to developing novel therapeutic strategies for endometrium-related infertility and malignancies.
KW - Adenomyosis
KW - Autophagy
KW - Endometrial Cancer
KW - Endometrial Hyperplasia
KW - Endometriosis
KW - Endometrium
KW - Uterine Fibroids/Leiomyoma
UR - http://www.scopus.com/inward/record.url?scp=85104882865&partnerID=8YFLogxK
U2 - 10.1007/s43032-021-00587-2
DO - 10.1007/s43032-021-00587-2
M3 - Review article
C2 - 33877643
AN - SCOPUS:85104882865
SN - 1933-7191
VL - 29
SP - 1054
EP - 1067
JO - Reproductive Sciences
JF - Reproductive Sciences
IS - 4
ER -