The Multifaceted Role of Autophagy in Endometrium Homeostasis and Disease

Pooja Popli, Ally J. Sun, Ramakrishna Kommagani

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Autophagy is a conserved fundamental cellular process with a primary function of catabolizing harmful or surplus cellular contents such as protein aggregates, dysfunctional/long-lived organelles, intracellular pathogens, and storage nutrients. An increasing body of evidence reveals that basal autophagy is essential for maintaining endometrial homeostasis and mediating endometrial-specific functions, including menstrual cycle, embryo implantation, and decidualization. However, perturbed levels of autophagy can lead to severe endometrial pathologies, including endometriosis, endometrial hyperplasia, endometrial cancer, adenomyosis, and leiomyoma. This review highlights the most recent findings on the activity, regulation, and function of autophagy in endometrium physiology and pathology. Understanding the mechanistic roles of autophagy in endometrium homeostasis and disease is key to developing novel therapeutic strategies for endometrium-related infertility and malignancies.

Original languageEnglish
Pages (from-to)1054-1067
Number of pages14
JournalReproductive Sciences
Volume29
Issue number4
DOIs
StatePublished - Apr 2022

Keywords

  • Adenomyosis
  • Autophagy
  • Endometrial Cancer
  • Endometrial Hyperplasia
  • Endometriosis
  • Endometrium
  • Uterine Fibroids/Leiomyoma

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