TY - JOUR
T1 - The multifaceted biology of plasmacytoid dendritic cells
AU - Swiecki, Melissa
AU - Colonna, Marco
N1 - Funding Information:
The authors greatly appreciate the feedback and helpful suggestions from M. Cella, S. Gilfillan, B. Reizis, M. Sanjuan and A. Krug. M.S. was supported by K01DK095972 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
Publisher Copyright:
© 2015 Macmillan Publishers Limited. All rights reserved.
PY - 2015/8/25
Y1 - 2015/8/25
N2 - Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in the production of type I interferons (IFNs). pDCs promote antiviral immune responses and have been implicated in the pathogenesis of autoimmune diseases that are characterized by a type I IFN signature. However, pDCs can also induce tolerogenic immune responses. In this Review, we summarize recent progress in the field of pDC biology, focusing on the molecular mechanisms that regulate the development and functions of pDCs, the pathways involved in their sensing of pathogens and endogenous nucleic acids, their functions at mucosal sites, and their roles in infection, autoimmunity and cancer.
AB - Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in the production of type I interferons (IFNs). pDCs promote antiviral immune responses and have been implicated in the pathogenesis of autoimmune diseases that are characterized by a type I IFN signature. However, pDCs can also induce tolerogenic immune responses. In this Review, we summarize recent progress in the field of pDC biology, focusing on the molecular mechanisms that regulate the development and functions of pDCs, the pathways involved in their sensing of pathogens and endogenous nucleic acids, their functions at mucosal sites, and their roles in infection, autoimmunity and cancer.
UR - http://www.scopus.com/inward/record.url?scp=84937967684&partnerID=8YFLogxK
U2 - 10.1038/nri3865
DO - 10.1038/nri3865
M3 - Review article
C2 - 26160613
AN - SCOPUS:84937967684
SN - 1474-1733
VL - 15
SP - 471
EP - 485
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 8
ER -