The mTOR Pathway and Aging

Katherine H. Schreiber; Monique N. O'Leary; Brian K. Kennedy

doi:10.1016/B978-0-12-411596-5.00002-2

The mTOR Pathway and Aging

Katherine H. Schreiber
, Monique N. O'Leary
, Brian K. Kennedy

Department of Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

7 Scopus citations

Abstract

The target of rapamycin (TOR) signaling pathway acts as a molecular switch to regulate cellular growth and proliferation in response to nutrients. This pathway is implicated in a number of pathological conditions, including cancer, metabolic disease, and cardiovascular disease, in addition to its role in the aging process in general. Inhibiting this integral pathway is one of the best-characterized methods to extend lifespan in model organisms. Here, we review what is currently known about the regulation of this pathway and the role of mTOR in aging and age-related disease progression. We also discuss potential therapies aimed at targeting this cellular regulator.

Original language	English
Title of host publication	Handbook of the Biology of Aging
Subtitle of host publication	Eighth Edition
Publisher	Elsevier Inc.
Pages	55-81
Number of pages	27
ISBN (Electronic)	9780124116207
ISBN (Print)	9780124115965
DOIs	https://doi.org/10.1016/B978-0-12-411596-5.00002-2
State	Published - 2016

Keywords

Age-related diseases
Aging
Dietary restriction
MTOR
Rapamycin

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10.1016/B978-0-12-411596-5.00002-2

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AU - Schreiber, Katherine H.

AU - O'Leary, Monique N.

AU - Kennedy, Brian K.

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AB - The target of rapamycin (TOR) signaling pathway acts as a molecular switch to regulate cellular growth and proliferation in response to nutrients. This pathway is implicated in a number of pathological conditions, including cancer, metabolic disease, and cardiovascular disease, in addition to its role in the aging process in general. Inhibiting this integral pathway is one of the best-characterized methods to extend lifespan in model organisms. Here, we review what is currently known about the regulation of this pathway and the role of mTOR in aging and age-related disease progression. We also discuss potential therapies aimed at targeting this cellular regulator.

KW - Age-related diseases

KW - Aging

KW - Dietary restriction

KW - MTOR

KW - Rapamycin

UR - https://www.scopus.com/pages/publications/84967109579

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SN - 9780124115965

SP - 55

EP - 81

BT - Handbook of the Biology of Aging

PB - Elsevier Inc.

ER -

The mTOR Pathway and Aging

Abstract

Keywords

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