The molecular mechanisms of melanoma tumorigenesis: An update

L. Gao, H. Zhao, L. A. Cornelius

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Therapeutic resistance and proclivity for metastasis cast the dismal prognosis of cutaneous melanoma. Although recent discoveries in genetic, epidemiological and genomic studies bring some hope of improved understanding of melanoma pathogenesis, questions regarding underlying molecular heterogeneity of melanoma genesis remain. Mining these complexities will hopefully reveal clues essential to understanding disease pathogenesis, clinical behavior and response to therapy. Current advances in high-resolution genome-wide technologies, as well as gene-specific mutational analysis, in conjunction with genetic and phenotypic analyses, improved animal models, may ultimately help to better define the seminal molecular events contributing to disease pathogenesis and ultimately identify more effective therapeutic targets.

Original languageEnglish
Pages (from-to)71-82
Number of pages12
JournalGiornale Italiano di Dermatologia e Venereologia
Volume142
Issue number2
StatePublished - Apr 2007

Keywords

  • AKT
  • Genes, p53
  • MITF protein, human
  • Melanoma
  • PI-3K

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