The molecular basis of antibody-mediated neutralization of West Nile virus

Theodore Oliphant, Michael S. Diamond

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

The study of the interaction between the West Nile virus envelope protein and monoclonal antibodies has provided insight into the molecular mechanisms of neutralization. Structural studies have identified an epitope on the lateral ridge of domain III of the West Nile virus E protein that is recognized by antibodies with the strongest neutralizing activity in vitro and in vivo. Antibodies that bind to this epitope are particularly inhibitory because they block infection at a post-attachment step and at concentrations that result in a low occupancy of the available sites on the virion.

Original languageEnglish
Pages (from-to)885-892
Number of pages8
JournalExpert opinion on biological therapy
Volume7
Issue number6
DOIs
StatePublished - Jun 1 2007

Keywords

  • Affinity
  • Antibody
  • Antibody-dependent enhancement
  • Epitope
  • Neutralization
  • West Nile virus

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