Abstract
Nicotinamide nucleotide transhydrogenase (Nnt) detoxifies reactive oxygen species (ROS), byproducts of mitochondrial metabolism that, when accumulated, can decrease mitochondrial ATP production. In this issue of Cell Metabolism, Freeman et al. (2006) demonstrate that Nnt in pancreatic β cells is important for insulin release. Their compelling data highlight the critical roles for ATP generation and subsequent closure of KATP channels for insulin secretion.
Original language | English |
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Pages (from-to) | 5-7 |
Number of pages | 3 |
Journal | Cell metabolism |
Volume | 3 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2006 |