Nicotinamide nucleotide transhydrogenase (Nnt) detoxifies reactive oxygen species (ROS), byproducts of mitochondrial metabolism that, when accumulated, can decrease mitochondrial ATP production. In this issue of Cell Metabolism, Freeman et al. (2006) demonstrate that Nnt in pancreatic β cells is important for insulin release. Their compelling data highlight the critical roles for ATP generation and subsequent closure of KATP channels for insulin secretion.

Original languageEnglish
Pages (from-to)5-7
Number of pages3
JournalCell metabolism
Issue number1
StatePublished - Jan 2006


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