The mitochondria and insulin release: Nnt just a passing relationship

Research output: Contribution to journalShort survey

6 Scopus citations


Nicotinamide nucleotide transhydrogenase (Nnt) detoxifies reactive oxygen species (ROS), byproducts of mitochondrial metabolism that, when accumulated, can decrease mitochondrial ATP production. In this issue of Cell Metabolism, Freeman et al. (2006) demonstrate that Nnt in pancreatic β cells is important for insulin release. Their compelling data highlight the critical roles for ATP generation and subsequent closure of KATP channels for insulin secretion.

Original languageEnglish
Pages (from-to)5-7
Number of pages3
JournalCell metabolism
Issue number1
StatePublished - Jan 1 2006

Fingerprint Dive into the research topics of 'The mitochondria and insulin release: Nnt just a passing relationship'. Together they form a unique fingerprint.

  • Cite this