The mitochondria and insulin release: Nnt just a passing relationship

Research output: Contribution to journalShort survey

6 Scopus citations

Abstract

Nicotinamide nucleotide transhydrogenase (Nnt) detoxifies reactive oxygen species (ROS), byproducts of mitochondrial metabolism that, when accumulated, can decrease mitochondrial ATP production. In this issue of Cell Metabolism, Freeman et al. (2006) demonstrate that Nnt in pancreatic β cells is important for insulin release. Their compelling data highlight the critical roles for ATP generation and subsequent closure of KATP channels for insulin secretion.

Original languageEnglish
Pages (from-to)5-7
Number of pages3
JournalCell metabolism
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2006

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