The microbiome, cancer, and cancer therapy

Beth A. Helmink, M. A.Wadud Khan, Amanda Hermann, Vancheswaran Gopalakrishnan, Jennifer A. Wargo

Research output: Contribution to journalReview articlepeer-review

419 Scopus citations

Abstract

With the advent of next-generation sequencing, we have an unprecedented ability to study tumor and host genomes as well as those of the vast array of microorganisms that exist within living organisms. Evidence now suggests that these microbes may confer susceptibility to certain cancers and may also influence response to therapeutics. A prime example of this is seen with immunotherapy, for which gut microbes have been implicated in influencing therapeutic responses in preclinical models and patient cohorts. However, these microbes may influence responses to other forms of therapy as well and may also affect treatment-associated toxicity. Based on these influences, there is growing interest in targeting these microbes in the treatment of cancer and other diseases. Yet complexities exist, and a deeper understanding of host–microbiome interactions is critical to realization of the full potential of such approaches. These concepts and the means through which such findings may be translated into the clinic will be discussed herein.

Original languageEnglish
Pages (from-to)377-388
Number of pages12
JournalNature medicine
Volume25
Issue number3
DOIs
StatePublished - Mar 1 2019

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