The membrane-water interface region of membrane proteins: Structural bias and the anti-snorkeling effect

Jie Liang; Larisa Adamian; Ronald Jackups

doi:10.1016/j.tibs.2005.05.003

The membrane-water interface region of membrane proteins: Structural bias and the anti-snorkeling effect

Jie Liang
, Larisa Adamian
, Ronald Jackups

Division of Laboratory and Genomic Medicine

Research output: Contribution to journal › Short survey › peer-review

33 Scopus citations

Abstract

Membrane proteins have important roles in many cellular processes. Computational analysis of their sequences and structures has provided much insight into the organizing principles of transmembrane helices. In a recent study, the membrane-water interface region was examined in detail for the first time. The results have revealed that this interface region has an important role in constraining protein secondary structure. This study raises new questions and opens up new directions for studying membrane proteins.

Original language	English
Pages (from-to)	355-357
Number of pages	3
Journal	Trends in biochemical sciences
Volume	30
Issue number	7
DOIs	https://doi.org/10.1016/j.tibs.2005.05.003
State	Published - Jul 2005

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10.1016/j.tibs.2005.05.003

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title = "The membrane-water interface region of membrane proteins: Structural bias and the anti-snorkeling effect",

abstract = "Membrane proteins have important roles in many cellular processes. Computational analysis of their sequences and structures has provided much insight into the organizing principles of transmembrane helices. In a recent study, the membrane-water interface region was examined in detail for the first time. The results have revealed that this interface region has an important role in constraining protein secondary structure. This study raises new questions and opens up new directions for studying membrane proteins.",

author = "Jie Liang and Larisa Adamian and Ronald Jackups",

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T1 - The membrane-water interface region of membrane proteins

T2 - Structural bias and the anti-snorkeling effect

AU - Liang, Jie

AU - Adamian, Larisa

AU - Jackups, Ronald

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Y1 - 2005/7

N2 - Membrane proteins have important roles in many cellular processes. Computational analysis of their sequences and structures has provided much insight into the organizing principles of transmembrane helices. In a recent study, the membrane-water interface region was examined in detail for the first time. The results have revealed that this interface region has an important role in constraining protein secondary structure. This study raises new questions and opens up new directions for studying membrane proteins.

AB - Membrane proteins have important roles in many cellular processes. Computational analysis of their sequences and structures has provided much insight into the organizing principles of transmembrane helices. In a recent study, the membrane-water interface region was examined in detail for the first time. The results have revealed that this interface region has an important role in constraining protein secondary structure. This study raises new questions and opens up new directions for studying membrane proteins.

UR - https://www.scopus.com/pages/publications/21744459067

U2 - 10.1016/j.tibs.2005.05.003

DO - 10.1016/j.tibs.2005.05.003

M3 - Short survey

C2 - 15935679

AN - SCOPUS:21744459067

SN - 0968-0004

VL - 30

SP - 355

EP - 357

JO - Trends in biochemical sciences

JF - Trends in biochemical sciences

IS - 7

ER -

The membrane-water interface region of membrane proteins: Structural bias and the anti-snorkeling effect

Abstract

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