The membrane-water interface region of membrane proteins: Structural bias and the anti-snorkeling effect

Jie Liang, Larisa Adamian, Ronald Jackups

Research output: Contribution to journalShort survey

26 Scopus citations

Abstract

Membrane proteins have important roles in many cellular processes. Computational analysis of their sequences and structures has provided much insight into the organizing principles of transmembrane helices. In a recent study, the membrane-water interface region was examined in detail for the first time. The results have revealed that this interface region has an important role in constraining protein secondary structure. This study raises new questions and opens up new directions for studying membrane proteins.

Original languageEnglish
Pages (from-to)355-357
Number of pages3
JournalTrends in biochemical sciences
Volume30
Issue number7
DOIs
StatePublished - Jul 2005
Externally publishedYes

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