TY - JOUR
T1 - The mediating effect of anxiety on the association between residual neurological impairment and post-stroke participation among persons with and without post-stroke depression
AU - Randolph, Samantha
AU - Lee, Yejin
AU - Nicholas, Marjorie L.
AU - Connor, Lisa Tabor
N1 - Publisher Copyright:
© 2023 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2023
Y1 - 2023
N2 - Previous research has reported that residual neurological impairment and emotional factors play a role in regaining successful participation post-stroke. The objective of this study was to investigate the mediating impact of anxiety on the association between residual neurological impairment and participation in survivors with and without post-stroke depressive symptoms. Participants (N = 79) were classified into 2 categories, those with post-stroke depressive symptoms (N = 40) and those without post-stroke depressive symptoms (N = 39). Variables measured in this study: residual neurological impairment (NIH Stroke Scale Score), participation (Reintegration to Normal Living Index), depressive symptoms (Patient Health Questionnaire-9), and trait anxiety (State-Trait Anxiety Inventory). A regression-based mediation analysis was conducted for each group of participants. The majority of participants had some level of anxiety. Residual neurological impairment predicted participation in stroke survivors both with (β = -.45, p =.003) and without (β = -.45, p =.004) post-stroke depressive symptoms. Anxiety mediated this relationship in participants with depressive symptoms (β = -.19, 95% CI = -.361 ∼ -.049), but not in participants without depressive symptoms (β = -.18, 95% CI = -.014 ∼.378). Depressive and anxious symptoms should both be addressed to best facilitate participation by stroke survivors.
AB - Previous research has reported that residual neurological impairment and emotional factors play a role in regaining successful participation post-stroke. The objective of this study was to investigate the mediating impact of anxiety on the association between residual neurological impairment and participation in survivors with and without post-stroke depressive symptoms. Participants (N = 79) were classified into 2 categories, those with post-stroke depressive symptoms (N = 40) and those without post-stroke depressive symptoms (N = 39). Variables measured in this study: residual neurological impairment (NIH Stroke Scale Score), participation (Reintegration to Normal Living Index), depressive symptoms (Patient Health Questionnaire-9), and trait anxiety (State-Trait Anxiety Inventory). A regression-based mediation analysis was conducted for each group of participants. The majority of participants had some level of anxiety. Residual neurological impairment predicted participation in stroke survivors both with (β = -.45, p =.003) and without (β = -.45, p =.004) post-stroke depressive symptoms. Anxiety mediated this relationship in participants with depressive symptoms (β = -.19, 95% CI = -.361 ∼ -.049), but not in participants without depressive symptoms (β = -.18, 95% CI = -.014 ∼.378). Depressive and anxious symptoms should both be addressed to best facilitate participation by stroke survivors.
KW - Anxiety
KW - Depression
KW - Mediation
KW - Participation
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=85146241402&partnerID=8YFLogxK
U2 - 10.1080/09602011.2023.2165115
DO - 10.1080/09602011.2023.2165115
M3 - Article
C2 - 36630107
AN - SCOPUS:85146241402
SN - 0960-2011
JO - Neuropsychological Rehabilitation
JF - Neuropsychological Rehabilitation
ER -