The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase

Navin Viswakarma; Yuzhi Jia; Liang Bai; Qian Gao; Bingliang Lin; Xiaohong Zhang; Parimal Misra; Ajay Rana; Sanjay Jain; Frank J. Gonzalez; Yi Jun Zhu; Bayar Thimmapaya; Janardan K. Reddy

doi:10.1074/jbc.M113.486696

The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase

Navin Viswakarma, Yuzhi Jia, Liang Bai, Qian Gao, Bingliang Lin, Xiaohong Zhang, Parimal Misra, Ajay Rana, Sanjay Jain, Frank J. Gonzalez, Yi Jun Zhu, Bayar Thimmapaya, Janardan K. Reddy

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19 Scopus citations

Abstract

Background: The Med1 subunit of the Mediator complex orchestrates metabolic pathways of energy metabolism. Results: Overexpression of Med1 in liver enhances hepatocyte proliferation and the cellular energy sensor AMPK phosphorylates Med1. Conclusion: Med1 is essential for hepatocellular proliferation and energy homeostasis downstream to AMPK. Significance: Med1 and its phosphorylation by AMPK may have important implications in the pathophysiology of liver.

Original language	English
Pages (from-to)	27898-27911
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	288
Issue number	39
DOIs	https://doi.org/10.1074/jbc.M113.486696
State	Published - Sep 27 2013

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title = "The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase",

abstract = "Background: The Med1 subunit of the Mediator complex orchestrates metabolic pathways of energy metabolism. Results: Overexpression of Med1 in liver enhances hepatocyte proliferation and the cellular energy sensor AMPK phosphorylates Med1. Conclusion: Med1 is essential for hepatocellular proliferation and energy homeostasis downstream to AMPK. Significance: Med1 and its phosphorylation by AMPK may have important implications in the pathophysiology of liver.",

author = "Navin Viswakarma and Yuzhi Jia and Liang Bai and Qian Gao and Bingliang Lin and Xiaohong Zhang and Parimal Misra and Ajay Rana and Sanjay Jain and Gonzalez, {Frank J.} and Zhu, {Yi Jun} and Bayar Thimmapaya and Reddy, {Janardan K.}",

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doi = "10.1074/jbc.M113.486696",

language = "English",

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journal = "Journal of Biological Chemistry",

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T1 - The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase

AU - Viswakarma, Navin

AU - Jia, Yuzhi

AU - Bai, Liang

AU - Gao, Qian

AU - Lin, Bingliang

AU - Zhang, Xiaohong

AU - Misra, Parimal

AU - Rana, Ajay

AU - Jain, Sanjay

AU - Gonzalez, Frank J.

AU - Zhu, Yi Jun

AU - Thimmapaya, Bayar

AU - Reddy, Janardan K.

PY - 2013/9/27

Y1 - 2013/9/27

N2 - Background: The Med1 subunit of the Mediator complex orchestrates metabolic pathways of energy metabolism. Results: Overexpression of Med1 in liver enhances hepatocyte proliferation and the cellular energy sensor AMPK phosphorylates Med1. Conclusion: Med1 is essential for hepatocellular proliferation and energy homeostasis downstream to AMPK. Significance: Med1 and its phosphorylation by AMPK may have important implications in the pathophysiology of liver.

AB - Background: The Med1 subunit of the Mediator complex orchestrates metabolic pathways of energy metabolism. Results: Overexpression of Med1 in liver enhances hepatocyte proliferation and the cellular energy sensor AMPK phosphorylates Med1. Conclusion: Med1 is essential for hepatocellular proliferation and energy homeostasis downstream to AMPK. Significance: Med1 and its phosphorylation by AMPK may have important implications in the pathophysiology of liver.

UR - http://www.scopus.com/inward/record.url?scp=84884804685&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.486696

DO - 10.1074/jbc.M113.486696

M3 - Article

C2 - 23943624

AN - SCOPUS:84884804685

SN - 0021-9258

VL - 288

SP - 27898

EP - 27911

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 39

ER -

The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase

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