The mechanism of action of T7 DNA polymerase

Sylvie Doublié, Tom Ellenberger

Research output: Contribution to journalArticle

155 Scopus citations

Abstract

The recent crystal structure determination of T7 DNA polymerase complexed to a deoxynucleoside triphosphate and primer-template DNA has provided the first glimpse of a replicative DNA polymerase in a catalytic complex. The structure complements many functional and structural studies of this and other DNA polymerases, allowing a detailed evaluation of proposals for the mechanism of nucleotidyl transfer and the exploration of the basis for the high fidelity of template-directed DNA synthesis.

Original languageEnglish
Pages (from-to)704-712
Number of pages9
JournalCurrent Opinion in Structural Biology
Volume8
Issue number6
DOIs
StatePublished - Dec 1998

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