The mechanism and regulation of chromosomal V(D)J recombination

Craig H. Bassing; Wojciech Swat; Frederick W. Alt

doi:10.1016/S0092-8674(02)00675-X

The mechanism and regulation of chromosomal V(D)J recombination

Craig H. Bassing, Wojciech Swat, Frederick W. Alt

Division of Laboratory and Genomic Medicine

Research output: Contribution to journal › Review article › peer-review

730 Scopus citations

Abstract

V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease.

Original language	English
Pages (from-to)	S45-S55
Journal	Cell
Volume	109
Issue number	2 SUPPL. 1
DOIs	https://doi.org/10.1016/S0092-8674(02)00675-X
State	Published - 2002

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title = "The mechanism and regulation of chromosomal V(D)J recombination",

abstract = "V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease.",

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T1 - The mechanism and regulation of chromosomal V(D)J recombination

AU - Bassing, Craig H.

AU - Swat, Wojciech

AU - Alt, Frederick W.

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N2 - V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease.

AB - V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease.

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U2 - 10.1016/S0092-8674(02)00675-X

DO - 10.1016/S0092-8674(02)00675-X

M3 - Review article

C2 - 11983152

AN - SCOPUS:0036240127

SN - 0092-8674

VL - 109

SP - S45-S55

JO - Cell

JF - Cell

IS - 2 SUPPL. 1

ER -

The mechanism and regulation of chromosomal V(D)J recombination

Abstract

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