The mechanism and regulation of chromosomal V(D)J recombination

Craig H. Bassing, Wojciech Swat, Frederick W. Alt

Research output: Contribution to journalReview articlepeer-review

682 Scopus citations

Abstract

V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease.

Original languageEnglish
Pages (from-to)S45-S55
JournalCell
Volume109
Issue number2 SUPPL. 1
DOIs
StatePublished - 2002

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