TY - JOUR
T1 - The maturing architecture of the brain's default network
AU - Fair, Damien A.
AU - Cohen, Alexander L.
AU - Dosenbach, Nico U.F.
AU - Church, Jessica A.
AU - Miezin, Francis M.
AU - Barch, Deanna M.
AU - Raichle, Marcus E.
AU - Petersen, Steven E.
AU - Schlaggar, Bradley L.
PY - 2008/3/25
Y1 - 2008/3/25
N2 - In recent years, the brains "default network," a set of regions characterized by decreased neural activity during goal-oriented tasks, has generated a significant amount of interest, as well as controversy. Much of the discussion has focused on the relationship of these regions to a "default mode" of brain function. In early studies, investigators suggested that, the brain's default mode supports "self-referential" or "introspective" mental activity. Subsequently, regions of the default network have been more specifically related to the "internal narrative," the "autobiographical self," "stimulus independent thought," "mentalizing," and most recently "self-projection." However, the extant literature on the function of the default network is limited to adults, i.e., after the system has reached maturity. We hypothesized that further insight into the network's functioning could be achieved by characterizing its development. In the current study, we used resting-state functional connectivity MRI (rs-fcMRI) to characterize the development of the brain's default network. We found that the default regions are only sparsely functionally connected at early school age (7-9 years old); over development, these regions integrate into a cohesive, interconnected network.
AB - In recent years, the brains "default network," a set of regions characterized by decreased neural activity during goal-oriented tasks, has generated a significant amount of interest, as well as controversy. Much of the discussion has focused on the relationship of these regions to a "default mode" of brain function. In early studies, investigators suggested that, the brain's default mode supports "self-referential" or "introspective" mental activity. Subsequently, regions of the default network have been more specifically related to the "internal narrative," the "autobiographical self," "stimulus independent thought," "mentalizing," and most recently "self-projection." However, the extant literature on the function of the default network is limited to adults, i.e., after the system has reached maturity. We hypothesized that further insight into the network's functioning could be achieved by characterizing its development. In the current study, we used resting-state functional connectivity MRI (rs-fcMRI) to characterize the development of the brain's default network. We found that the default regions are only sparsely functionally connected at early school age (7-9 years old); over development, these regions integrate into a cohesive, interconnected network.
KW - Connectivity
KW - Development
KW - Functional
KW - fMRI
UR - http://www.scopus.com/inward/record.url?scp=41649108053&partnerID=8YFLogxK
U2 - 10.1073/pnas.0800376105
DO - 10.1073/pnas.0800376105
M3 - Article
C2 - 18322013
AN - SCOPUS:41649108053
SN - 0027-8424
VL - 105
SP - 4028
EP - 4032
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 10
ER -