The matricellular protein thrombospondin-1 in lung inflammation and injury

Mohammadreza Tabary, Atish Gheware, Hernán F. Peñaloza, Janet S. Lee

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Matricellular proteins comprise a diverse group of molecular entities secreted into the extracellular space. They interact with the extracellular matrix (ECM), integrins, and other cell-surface receptors, and can alter matrix strength, cell attachment to the matrix, and cell-cell adhesion. A founding member of this group is thrombospondin-1 (TSP-1), a high molecular-mass homotrimeric glycoprotein. Given the importance of the matrix and ECM remodeling in the lung following injury, TSP-1 has been implicated in a number of lung pathologies. This review examines the role of TSP-1 as a damage controller in the context of lung inflammation, injury resolution, and repair in noninfectious and infectious models. This review also discusses the potential role of TSP-1 in human diseases as it relates to lung inflammation and injury.

Original languageEnglish
Pages (from-to)C857-C865
JournalAmerican Journal of Physiology - Cell Physiology
Issue number3
StatePublished - Sep 2022


  • lung inflammation
  • lung injury
  • matricellular protein
  • thrombospondin-1


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