The Management of Severe Sepsis and Septic Shock

Matthew R. Morrell, Scott T. Micek, Marin H. Kollef

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


The diagnosis and management of severe sepsis and septic shock is a complex and dynamic process. Newer evidence-based interventions are constantly being developed and implemented with the purpose of improving morbidity and mortality. Current investigations are being performed in hospital environments to determine the change in behaviors and clinical impact with the most recent recommendations. The use of standardized treatment protocols in addition to newer diagnostic and treatment modalities in patients who have severe sepsis and septic shock can continue to improve patient-related outcomes and the damaging effect of these diseases on society.

Original languageEnglish
Pages (from-to)485-501
Number of pages17
JournalInfectious disease clinics of North America
Issue number3
StatePublished - Sep 2009


  • Biomarkers
  • Empiric antibiotics
  • Goal-directed therapy
  • Septic shock
  • Severe sepsis
  • Vasoactive agents


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