The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4)

Kory J. Lavine, Alexander R. Pinto, Slava Epelman, Benjamin J. Kopecky, Xavier Clemente-Casares, James Godwin, Nadia Rosenthal, Jason C. Kovacic

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Macrophages are integral components of cardiac tissue and exert profound effects on the healthy and diseased heart. Paradigm shifting studies using advanced molecular techniques have revealed significant complexity within these macrophage populations that reside in the heart. In this final of a 4-part review series covering the macrophage in cardiovascular disease, the authors review the origins, dynamics, cell surface markers, and respective functions of each cardiac macrophage subset identified to date, including in the specific scenarios of myocarditis and after myocardial infarction. Looking ahead, a deeper understanding of the diverse and often dichotomous functions of cardiac macrophages will be essential for the development of targeted therapies to mitigate injury and orchestrate recovery of the diseased heart. Moreover, as macrophages are critical for cardiac healing, they are an emerging focus for therapeutic strategies aimed at minimizing cardiomyocyte death, ameliorating pathological cardiac remodeling, and for treating heart failure and after myocardial infarction.

Original languageEnglish
Pages (from-to)2213-2230
Number of pages18
JournalJournal of the American College of Cardiology
Volume72
Issue number18
DOIs
StatePublished - Oct 30 2018

Keywords

  • coronary angiogenesis
  • heart development
  • heart failure
  • macrophage
  • ontogeny

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    Lavine, K. J., Pinto, A. R., Epelman, S., Kopecky, B. J., Clemente-Casares, X., Godwin, J., Rosenthal, N., & Kovacic, J. C. (2018). The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4). Journal of the American College of Cardiology, 72(18), 2213-2230. https://doi.org/10.1016/j.jacc.2018.08.2149