The lymphatic system: Integral roles in immunity

Gwendalyn J. Randolph, Stoyan Ivanov, Bernd H. Zinselmeyer, Joshua P. Scallan

Research output: Contribution to journalReview articlepeer-review

92 Scopus citations

Abstract

The lymphatic vasculature is not considered a formal part of the immune system, but it is critical to immunity. One of its major roles is in the coordination of the trafficking of antigen and immune cells. However, other roles in immunity are emerging. Lymphatic endothelial cells, for example, directly present antigen or express factors that greatly influence the local environment. We cover these topics herein and discuss how other properties of the lymphatic vasculature, such as mechanisms of lymphatic contraction (which immunologists traditionally do not take into account), are nonetheless integral in the immune system. Much is yet unknown, and this nascent subject is ripe for exploration. We argue that to consider the impact of lymphatic biology in any given immunological interaction is a key step toward integrating immunology with organ physiology and ultimately many complex pathologies.

Original languageEnglish
Pages (from-to)31-52
Number of pages22
JournalAnnual Review of Immunology
Volume35
DOIs
StatePublished - Apr 26 2017

Keywords

  • Adhesion
  • Endothelium
  • Lymph
  • Lymph node
  • Migration

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