The localization and characterization of substance P and substance K in striatonigral neurons

Jin Moo Lee; Stafford McLean; John E. Maggio; Nadav Zamir; Robert H. Roth; Robert L. Eskay; Michael J. Bannon

doi:10.1016/0006-8993(86)90820-6

The localization and characterization of substance P and substance K in striatonigral neurons

Jin Moo Lee
, Stafford McLean
, John E. Maggio
, Nadav Zamir
, Robert H. Roth
, Robert L. Eskay
, Michael J. Bannon

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Specific substance P and substance K radioimmunoassays coupled to high-performance liquid chromatography were used to characterize striatal and nigral tachykinin immunoreactivity. Using these assays, authentic substance P and substance K acounted for nearly all substance P and substance K immunoreactivity, respectively. A series of coronal knife cuts of the striatum caused parallel depletions in nigral substance P and substance K, consistent with the possible colocalization of these tachykinins in striatonigral neurons.

Original language	English
Pages (from-to)	152-154
Number of pages	3
Journal	Brain Research
Volume	371
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(86)90820-6
State	Published - Apr 16 1986

Keywords

high-performance liquid chromatography
knife cut
neuromedin K
striatum
substance K
substance P
substantia nigra

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10.1016/0006-8993(86)90820-6

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title = "The localization and characterization of substance P and substance K in striatonigral neurons",

abstract = "Specific substance P and substance K radioimmunoassays coupled to high-performance liquid chromatography were used to characterize striatal and nigral tachykinin immunoreactivity. Using these assays, authentic substance P and substance K acounted for nearly all substance P and substance K immunoreactivity, respectively. A series of coronal knife cuts of the striatum caused parallel depletions in nigral substance P and substance K, consistent with the possible colocalization of these tachykinins in striatonigral neurons.",

keywords = "high-performance liquid chromatography, knife cut, neuromedin K, striatum, substance K, substance P, substantia nigra",

author = "Lee, \{Jin Moo\} and Stafford McLean and Maggio, \{John E.\} and Nadav Zamir and Roth, \{Robert H.\} and Eskay, \{Robert L.\} and Bannon, \{Michael J.\}",

note = "Funding Information: We thank Mr. Rolf Hanson for expert technical assistance and Mrs. Angelika Mayes for skilled preparation of this manuscript. This work was supported in part by USPHS Grants MH-25642 and MH-41388; Biomedical Research Support Grant RR05358 and the State of Connecticut.",

year = "1986",

month = apr,

day = "16",

doi = "10.1016/0006-8993(86)90820-6",

language = "English",

volume = "371",

pages = "152--154",

journal = "Brain Research",

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TY - JOUR

T1 - The localization and characterization of substance P and substance K in striatonigral neurons

AU - Lee, Jin Moo

AU - McLean, Stafford

AU - Maggio, John E.

AU - Zamir, Nadav

AU - Roth, Robert H.

AU - Eskay, Robert L.

AU - Bannon, Michael J.

N1 - Funding Information: We thank Mr. Rolf Hanson for expert technical assistance and Mrs. Angelika Mayes for skilled preparation of this manuscript. This work was supported in part by USPHS Grants MH-25642 and MH-41388; Biomedical Research Support Grant RR05358 and the State of Connecticut.

PY - 1986/4/16

Y1 - 1986/4/16

N2 - Specific substance P and substance K radioimmunoassays coupled to high-performance liquid chromatography were used to characterize striatal and nigral tachykinin immunoreactivity. Using these assays, authentic substance P and substance K acounted for nearly all substance P and substance K immunoreactivity, respectively. A series of coronal knife cuts of the striatum caused parallel depletions in nigral substance P and substance K, consistent with the possible colocalization of these tachykinins in striatonigral neurons.

AB - Specific substance P and substance K radioimmunoassays coupled to high-performance liquid chromatography were used to characterize striatal and nigral tachykinin immunoreactivity. Using these assays, authentic substance P and substance K acounted for nearly all substance P and substance K immunoreactivity, respectively. A series of coronal knife cuts of the striatum caused parallel depletions in nigral substance P and substance K, consistent with the possible colocalization of these tachykinins in striatonigral neurons.

KW - high-performance liquid chromatography

KW - knife cut

KW - neuromedin K

KW - striatum

KW - substance K

KW - substance P

KW - substantia nigra

UR - https://www.scopus.com/pages/publications/0022558778

U2 - 10.1016/0006-8993(86)90820-6

DO - 10.1016/0006-8993(86)90820-6

M3 - Article

C2 - 2423184

AN - SCOPUS:0022558778

SN - 0006-8993

VL - 371

SP - 152

EP - 154

JO - Brain Research

JF - Brain Research

IS - 1

ER -

The localization and characterization of substance P and substance K in striatonigral neurons

Abstract

Keywords

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