The localization and characterization of substance P and substance K in striatonigral neurons

Jin Moo Lee, Stafford McLean, John E. Maggio, Nadav Zamir, Robert H. Roth, Robert L. Eskay, Michael J. Bannon

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Specific substance P and substance K radioimmunoassays coupled to high-performance liquid chromatography were used to characterize striatal and nigral tachykinin immunoreactivity. Using these assays, authentic substance P and substance K acounted for nearly all substance P and substance K immunoreactivity, respectively. A series of coronal knife cuts of the striatum caused parallel depletions in nigral substance P and substance K, consistent with the possible colocalization of these tachykinins in striatonigral neurons.

Original languageEnglish
Pages (from-to)152-154
Number of pages3
JournalBrain Research
Volume371
Issue number1
DOIs
StatePublished - Apr 16 1986
Externally publishedYes

Keywords

  • high-performance liquid chromatography
  • knife cut
  • neuromedin K
  • striatum
  • substance K
  • substance P
  • substantia nigra

Fingerprint Dive into the research topics of 'The localization and characterization of substance P and substance K in striatonigral neurons'. Together they form a unique fingerprint.

  • Cite this

    Lee, J. M., McLean, S., Maggio, J. E., Zamir, N., Roth, R. H., Eskay, R. L., & Bannon, M. J. (1986). The localization and characterization of substance P and substance K in striatonigral neurons. Brain Research, 371(1), 152-154. https://doi.org/10.1016/0006-8993(86)90820-6