Manipulating thermogenesis could increase energy expenditure and improve metabolism. Brown fat is a major site of nonshivering thermogenesis, but other tissues, notably muscle and liver, can contribute to cold adaptation. In this issue, Simcox et al. (2017) demonstrate in cold-exposed mice that liver-generated acylcarnitines are required to fuel thermogenesis.

Original languageEnglish
Pages (from-to)454-455
Number of pages2
JournalCell metabolism
Issue number3
StatePublished - Sep 5 2017


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