The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring

Syeda Maheen Batool, Anudeep Yekula, Prerna Khanna, Tiffaney Hsia, Austin S. Gamblin, Emil Ekanayake, Ana K. Escobedo, Dong Gil You, Cesar M. Castro, Hyungsoon Im, Tugba Kilic, Michelle Andrea Garlin, Johan Skog, Daniela M. Dinulescu, Jonathan Dudley, Nishant Agrawal, Jordan Cheng, Fereidoun Abtin, Denise R. Aberle, David ChiaDavid Elashoff, Tristan Grognan, Kostyantyn Krysan, Scott S. Oh, Charles Strom, Michael Tu, Fang Wei, Rena R. Xian, Steven J. Skates, David Y. Zhang, Thi Trinh, Mark Watson, Rebecca Aft, Siddarth Rawal, Ashutosh Agarwal, Susan B. Kesmodel, Changhuei Yang, Cheng Shen, Fred H. Hochberg, David T.W. Wong, Abhijit A. Patel, Nickolas Papadopoulos, Chetan Bettegowda, Richard J. Cote, Sudhir Srivastava, Hakho Lee, Bob S. Carter, Leonora Balaj

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

The emerging field of liquid biopsy stands at the forefront of novel diagnostic strategies for cancer and other diseases. Liquid biopsy allows minimally invasive molecular characterization of cancers for diagnosis, patient stratification to therapy, and longitudinal monitoring. Liquid biopsy strategies include detection and monitoring of circulating tumor cells, cell-free DNA, and extracellular vesicles. In this review, we address the current understanding and the role of existing liquid-biopsy-based modalities in cancer diagnostics and monitoring. We specifically focus on the technical and clinical challenges associated with liquid biopsy and biomarker development being addressed by the Liquid Biopsy Consortium, established through the National Cancer Institute. The Liquid Biopsy Consortium has developed new methods/assays and validated existing methods/technologies to capture and characterize tumor-derived circulating cargo, as well as addressed existing challenges and provided recommendations for advancing biomarker assays.

Original languageEnglish
Article number101198
JournalCell Reports Medicine
Volume4
Issue number10
DOIs
StatePublished - Oct 17 2023

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