The lineage decisions of helper T cells

Kenneth M. Murphy, Steven L. Reiner

Research output: Contribution to journalReview article

1272 Scopus citations

Abstract

After encountering antigen, helper T (TH) cells undergo differentiation to effector cells, which can secrete high levels of interferon-γ, interleukin-4 (IL-4), IL-10 and other immunomodulators. How TH cells acquire, and remember, new patterns of gene expression is an area of intensive investigation. The process is remarkably plastic, with cytokines being key regulators. Extrinsic signals seem to be integrated into cell-intrinsic programming, in what is becoming an intriguing story of regulated development. We summarize the latest insights into mechanisms that govern the lineage choices that are made during TH-cell responses to foreign pathogens.

Original languageEnglish
Pages (from-to)933-944
Number of pages12
JournalNature Reviews Immunology
Volume2
Issue number12
DOIs
StatePublished - Dec 1 2002

Fingerprint Dive into the research topics of 'The lineage decisions of helper T cells'. Together they form a unique fingerprint.

  • Cite this