The lineage decisions of helper T cells

Kenneth M. Murphy; Steven L. Reiner

doi:10.1038/nri954

The lineage decisions of helper T cells

Kenneth M. Murphy, Steven L. Reiner

Research output: Contribution to journal › Review article › peer-review

1413 Scopus citations

Abstract

After encountering antigen, helper T (T_H) cells undergo differentiation to effector cells, which can secrete high levels of interferon-γ, interleukin-4 (IL-4), IL-10 and other immunomodulators. How T_H cells acquire, and remember, new patterns of gene expression is an area of intensive investigation. The process is remarkably plastic, with cytokines being key regulators. Extrinsic signals seem to be integrated into cell-intrinsic programming, in what is becoming an intriguing story of regulated development. We summarize the latest insights into mechanisms that govern the lineage choices that are made during T_H-cell responses to foreign pathogens.

Original language	English
Pages (from-to)	933-944
Number of pages	12
Journal	Nature Reviews Immunology
Volume	2
Issue number	12
DOIs	https://doi.org/10.1038/nri954
State	Published - Dec 2002

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The lineage decisions of helper T cells

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