The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway

Sharon S. McDaniel, Nicholas R. Rensing, Liu Lin Thio, Kelvin A. Yamada, Michael Wong

Research output: Contribution to journalArticle

123 Scopus citations

Abstract

The ketogenic diet (KD) is an effective treatment for epilepsy, but its mechanisms of action are poorly understood. Weinvestigated the hypothesis that the KD inhibits mammalian target of rapamycin (mTOR) pathway signaling. The expression of pS6 and pAkt, markers of mTOR pathway activation, was reduced in hippocampus and liver of rats fed KD. In the kainate model of epilepsy, KD blocked the hippocampal pS6 elevation that occurs after status epilepticus. Because mTOR signaling has been implicated in epileptogenesis, these results suggest that the KD may have anticonvulsant or antiepileptogenic actions via mTORpathway inhibition. Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)e7-e11
JournalEpilepsia
Volume52
Issue number3
DOIs
StatePublished - Mar 1 2011

Keywords

  • Epilepsy
  • Kainate
  • Rat
  • Seizure

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