TY - JOUR
T1 - The iron hand of uropathogenic Escherichia coli
T2 - The role of transition metal control in virulence
AU - Robinson, Anne E.
AU - Heffernan, James R.
AU - Henderson, Jeffrey P.
N1 - Funding Information:
The authors would like to acknowledge funding from NIH grants RO1 DK099534 and RO1 DK111930 as well as a Mr. and Mrs. Spencer T. Olin Fellowship for Women in Graduate Study to AER. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.
Publisher Copyright:
© 2018 Future Medicine Ltd.
PY - 2018
Y1 - 2018
N2 - The role of iron as a critical nutrient in pathogenic bacteria is widely regarded as having driven selection for iron acquisition systems among uropathogenic Escherichia coli (UPEC) isolates. Carriage of multiple transition metal acquisition systems in UPEC suggests that the human urinary tract manipulates metal-ion availability in many ways to resist infection. For siderophore systems in particular, recent studies have identified new roles for siderophore copper binding as well as production of siderophore-like inhibitors of iron uptake by other, competing bacterial species. Among these is a process of nutritional passivation of metal ions, in which uropathogens access these vital nutrients while simultaneously protecting themselves from their toxic potential. Here, we review these new findings within the current understanding of UPEC transition metal acquisition.
AB - The role of iron as a critical nutrient in pathogenic bacteria is widely regarded as having driven selection for iron acquisition systems among uropathogenic Escherichia coli (UPEC) isolates. Carriage of multiple transition metal acquisition systems in UPEC suggests that the human urinary tract manipulates metal-ion availability in many ways to resist infection. For siderophore systems in particular, recent studies have identified new roles for siderophore copper binding as well as production of siderophore-like inhibitors of iron uptake by other, competing bacterial species. Among these is a process of nutritional passivation of metal ions, in which uropathogens access these vital nutrients while simultaneously protecting themselves from their toxic potential. Here, we review these new findings within the current understanding of UPEC transition metal acquisition.
UR - http://www.scopus.com/inward/record.url?scp=85048928419&partnerID=8YFLogxK
U2 - 10.2217/fmb-2017-0295
DO - 10.2217/fmb-2017-0295
M3 - Review article
C2 - 29870278
AN - SCOPUS:85048928419
SN - 1746-0913
VL - 13
SP - 813
EP - 829
JO - Future microbiology
JF - Future microbiology
IS - 7
ER -