The interplay between neutrophils, complement, and microthrombi in COVID-19

Yu Zuo; Yogendra Kanthi; Jason S. Knight; Alfred H.J. Kim

doi:10.1016/j.berh.2021.101661

The interplay between neutrophils, complement, and microthrombi in COVID-19

Yu Zuo, Yogendra Kanthi, Jason S. Knight, Alfred H.J. Kim

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

As of the end of 2020, coronavirus disease 2019 (COVID-19) remains a global healthcare challenge with alarming death tolls. In the absence of targeted therapies, supportive care continues to be the mainstay of treatment. The hallmark of severe COVID-19 is a thromboinflammatory storm driven by innate immune responses. This manifests clinically as acute respiratory distress syndrome, and in some patients, widespread thrombotic microangiopathy. Neutrophils and complement are key players in the innate immune system, and their role in perpetuating fatal severe COVID-19 continues to receive increasing attention. Here, we review the interplay between neutrophils, neutrophil extracellular traps, and complement in COVID-19 immunopathology, and highlight potential therapeutic strategies to combat these pathways.

Original language	English
Article number	101661
Journal	Best Practice and Research: Clinical Rheumatology
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/j.berh.2021.101661
State	Published - Mar 2021

Keywords

COVID-19
Complement
Innate immunity
NETs
Neutrophil extracellular traps
SARS-CoV-2
Thrombotic microangiopathy

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10.1016/j.berh.2021.101661

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title = "The interplay between neutrophils, complement, and microthrombi in COVID-19",

abstract = "As of the end of 2020, coronavirus disease 2019 (COVID-19) remains a global healthcare challenge with alarming death tolls. In the absence of targeted therapies, supportive care continues to be the mainstay of treatment. The hallmark of severe COVID-19 is a thromboinflammatory storm driven by innate immune responses. This manifests clinically as acute respiratory distress syndrome, and in some patients, widespread thrombotic microangiopathy. Neutrophils and complement are key players in the innate immune system, and their role in perpetuating fatal severe COVID-19 continues to receive increasing attention. Here, we review the interplay between neutrophils, neutrophil extracellular traps, and complement in COVID-19 immunopathology, and highlight potential therapeutic strategies to combat these pathways.",

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AU - Kanthi, Yogendra

AU - Knight, Jason S.

AU - Kim, Alfred H.J.

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The interplay between neutrophils, complement, and microthrombi in COVID-19

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