The interaction of sleep and amyloid deposition on cognitive performance

Jennifer R.V. Molano, Catherine M. Roe, Yo El S. Ju

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Sleep difficulties are emerging as a risk factor for dementia. This study examined the effect of sleep and amyloid deposition on cognitive performance in cognitively normal adults. Sleep efficiency was determined by actigraphy. Cerebrospinal fluid Aβ42 levels <500 pg mL−1, indicating amyloid deposition, was present in 23 participants. Psychometric tests included the Free and Cued Selective Reminding Test, Trail Making Test A and B, Animal Fluency, Letter Number Sequencing, and the Mini Mental State Examination. The interaction term of sleep efficiency and amyloid deposition status was a significant predictor of memory performance as measured by total Selective Reminding Test scores. While Trail Making Test B performance was worse in those with amyloid deposition, sleep measures did not have an additive effect. In this study, amyloid deposition was associated with worse cognitive performance, and poor sleep efficiency specifically modified the effect of amyloid deposition on memory performance.

Original languageEnglish
Pages (from-to)288-292
Number of pages5
JournalJournal of Sleep Research
Volume26
Issue number3
DOIs
StatePublished - Jun 2017

Keywords

  • Alzheimer's disease
  • biomarkers
  • neurodegeneration

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