@article{71ae39fbae954baa92d37dd92fbcac12,
title = "The interaction of sleep and amyloid deposition on cognitive performance",
abstract = "Sleep difficulties are emerging as a risk factor for dementia. This study examined the effect of sleep and amyloid deposition on cognitive performance in cognitively normal adults. Sleep efficiency was determined by actigraphy. Cerebrospinal fluid Aβ42 levels <500 pg mL−1, indicating amyloid deposition, was present in 23 participants. Psychometric tests included the Free and Cued Selective Reminding Test, Trail Making Test A and B, Animal Fluency, Letter Number Sequencing, and the Mini Mental State Examination. The interaction term of sleep efficiency and amyloid deposition status was a significant predictor of memory performance as measured by total Selective Reminding Test scores. While Trail Making Test B performance was worse in those with amyloid deposition, sleep measures did not have an additive effect. In this study, amyloid deposition was associated with worse cognitive performance, and poor sleep efficiency specifically modified the effect of amyloid deposition on memory performance.",
keywords = "Alzheimer's disease, biomarkers, neurodegeneration",
author = "Molano, {Jennifer R.V.} and Roe, {Catherine M.} and Ju, {Yo El S.}",
note = "Funding Information: Collection and management of research in this publication was supported by the National Institute on Aging (P50AG005681, P01AG003991 and P01AG026276); Fred Simmons and Olga Mohan, and the Charles F. and Joanne Knight Alzheimer's Research Initiative of the Washington University Knight Alzheimer's Disease Research Center. Collection, management and analysis of data for research in this publication was supported by the National Institute of Neurological Diseases and Stroke (K23NS089922), and the Washington University Institute of Clinical and Translational Sciences grant UL1TR000448, sub-award KL2TR000450, from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official view of the NIH. No funder or sponsor had a role in design and conduct of the study, interpretation of the data, or preparation, review or approval of the manuscript. There were no off-label or investigational use materials in this study. Publisher Copyright: {\textcopyright} 2016 European Sleep Research Society",
year = "2017",
month = jun,
doi = "10.1111/jsr.12474",
language = "English",
volume = "26",
pages = "288--292",
journal = "Journal of Sleep Research",
issn = "0962-1105",
number = "3",
}