The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form

Matteo G. Levisetti, Anish Suri, Shirley J. Petzold, Emil R. Unanue

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Several naturally occurring anti-insulin CD4 T cells were isolated from islet infiltrates of NOD mice. In accordance with the results of others, these T cells recognized the segment of the β-chain from residues 9-23. Peptides encompassing the B:(9-23) sequence bound weakly to I-Ag7 in two main contiguous registers in which two residues at the carboxyl end, P20Gly and P21Glu, influenced binding and T cell reactivity. Naturally occurring insulin-reactive T cells exhibited differing reactivities with the carboxyl-terminal amino acids, although various single residue changes in either the flanks or the core segments affected T cell responses. The insulin peptides represent another example of a weak MHC-binding ligand that is highly immunogenic, giving rise to distinct populations of autoimmune T cells.

Original languageEnglish
Pages (from-to)6051-6057
Number of pages7
JournalJournal of Immunology
Volume178
Issue number10
DOIs
StatePublished - May 15 2007

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