The influence of vacular function on left ventricular contraction/relaxation coupling

Mustafa Karamanoglu, Sándor J. Kovács

Research output: Contribution to journalConference articlepeer-review


Indexes of ventricular function have conventionally been classified into indexes of systolic (contractile) or diastolic (relaxation/stiffness) function. Systolic indexes include maximum elastance (Emax) or equivalently the end-systolic pressure volume relation (ESPVR) and left ventricular ejection fraction (LVEF). Diastolic indexes include the time constant of isovolumic relaxation (τ) and the end-diastolic pressure-volume relation (EDPVR). The conceptualization of ventricular contraction/relaxation coupling presents a challenge when mechanical events of the cardiac cycle are depicted in conventional pressure (P) or volume (V) terms. Additional conceptual difficulty arises when ventricular/vascular coupling is considered using P, V variables. In this preliminary work, we introduce the concept of thermodynamic phase-plane (TPP) defined by the PdV and VdP axes. TPP allows all cardiac mechanical events and their coupling to the vasculature to be geometrically depicted and simultaneously analyzed. Conventional systolic and diastolic function indexes are easily recovered, novel indexes of contraction-relaxation coupling are discernible and the influence of vascular function can be assessed.

Original languageEnglish
Pages (from-to)1215-1217
Number of pages3
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002


  • Arterial function
  • Contraction/relaxation coupling
  • Ventricular function
  • Ventricular/vascular coupling


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