The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy

Vancheswaran Gopalakrishnan, Beth A. Helmink, Christine N. Spencer, Alexandre Reuben, Jennifer A. Wargo

Research output: Contribution to journalReview articlepeer-review

457 Scopus citations

Abstract

The microbiome is receiving significant attention given its influence on a host of human diseases including cancer. Its role in response to cancer treatment is becoming increasingly apparent, with evidence suggesting that modulating the gut microbiome may affect responses to numerous forms of cancer therapy. A working knowledge of the microbiome is vital as we move forward in this age of precision medicine, and an understanding of the microbiome's influence on immune responses and cancer is key. It is also important to understand factors influencing the gut microbiome and strategies to manipulate the microbiome to augment therapeutic responses. The microbiome is receiving significant attention given its influence on a host of human diseases including cancer. Its role in response to cancer treatment is becoming increasingly apparent, with evidence suggesting that modulating the gut microbiome may affect responses to numerous forms of cancer therapy. A working knowledge of the microbiome is vital as we move forward in this age of precision medicine, and an understanding of the microbiome's influence on immune responses and cancer is key. It is also important to understand factors influencing the gut microbiome and strategies to manipulate the microbiome to augment therapeutic responses.

Original languageEnglish
Pages (from-to)570-580
Number of pages11
JournalCancer Cell
Volume33
Issue number4
DOIs
StatePublished - Apr 9 2018

Keywords

  • cancer
  • cancer immunosurveillance
  • gut microbiome
  • immunity
  • immunotherapy
  • immunotherapy response
  • immunotherapy toxicity
  • microbiome
  • microbiome manipulation
  • microbiota

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