TY - JOUR
T1 - The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy
AU - Gopalakrishnan, Vancheswaran
AU - Helmink, Beth A.
AU - Spencer, Christine N.
AU - Reuben, Alexandre
AU - Wargo, Jennifer A.
N1 - Funding Information:
J.A.W. has honoraria from speakers' bureau of Dava Oncology, Bristol-Myers Squibb, and Illumina, and is an advisory board member for GlaxoSmithKline, Novartis, and Roche/Genentech. J.A.W. is supported by the U.S- Israel Binational Science Foundation (201332), Kennedy Memorial Foundation (0727030), the Melanoma Research Alliance (4022024), American Association for Cancer Research Stand Up To Cancer (SU2C-AACR-IRG-19-17), Department of Defense (W81XWH-16-1-0121), MD Anderson Cancer Center Multidisciplinary Research Program Grant, Andrew Sabin Family Fellows Program, and MD Anderson Cancer Center's Melanoma Moon Shots Program. J.A.W. is a member of the Parker Institute for Cancer Immunotherapy at MD Anderson Cancer Center. A.R. is supported by the Kimberley Clarke Foundation Award for Scientific Achievement provided by the Odyssey Fellowship program at The University of Texas MD Anderson Cancer Center.
Funding Information:
J.A.W. has honoraria from speakers' bureau of Dava Oncology, Bristol-Myers Squibb, and Illumina, and is an advisory board member for GlaxoSmithKline, Novartis, and Roche/Genentech. J.A.W. is supported by the U.S- Israel Binational Science Foundation (201332), Kennedy Memorial Foundation (0727030), the Melanoma Research Alliance (4022024), American Association for Cancer Research Stand Up To Cancer (SU2C-AACR-IRG-19-17), Department of Defense (W81XWH-16-1-0121), MD Anderson Cancer Center Multidisciplinary Research Program Grant, Andrew Sabin Family Fellows Program, and MD Anderson Cancer Center's Melanoma Moon Shots Program. J.A.W. is a member of the Parker Institute for Cancer Immunotherapy at MD Anderson Cancer Center. A.R. is supported by the Kimberley Clarke Foundation Award for Scientific Achievement provided by the Odyssey Fellowship program at The University of Texas MD Anderson Cancer Center.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/4/9
Y1 - 2018/4/9
N2 - The microbiome is receiving significant attention given its influence on a host of human diseases including cancer. Its role in response to cancer treatment is becoming increasingly apparent, with evidence suggesting that modulating the gut microbiome may affect responses to numerous forms of cancer therapy. A working knowledge of the microbiome is vital as we move forward in this age of precision medicine, and an understanding of the microbiome's influence on immune responses and cancer is key. It is also important to understand factors influencing the gut microbiome and strategies to manipulate the microbiome to augment therapeutic responses. The microbiome is receiving significant attention given its influence on a host of human diseases including cancer. Its role in response to cancer treatment is becoming increasingly apparent, with evidence suggesting that modulating the gut microbiome may affect responses to numerous forms of cancer therapy. A working knowledge of the microbiome is vital as we move forward in this age of precision medicine, and an understanding of the microbiome's influence on immune responses and cancer is key. It is also important to understand factors influencing the gut microbiome and strategies to manipulate the microbiome to augment therapeutic responses.
AB - The microbiome is receiving significant attention given its influence on a host of human diseases including cancer. Its role in response to cancer treatment is becoming increasingly apparent, with evidence suggesting that modulating the gut microbiome may affect responses to numerous forms of cancer therapy. A working knowledge of the microbiome is vital as we move forward in this age of precision medicine, and an understanding of the microbiome's influence on immune responses and cancer is key. It is also important to understand factors influencing the gut microbiome and strategies to manipulate the microbiome to augment therapeutic responses. The microbiome is receiving significant attention given its influence on a host of human diseases including cancer. Its role in response to cancer treatment is becoming increasingly apparent, with evidence suggesting that modulating the gut microbiome may affect responses to numerous forms of cancer therapy. A working knowledge of the microbiome is vital as we move forward in this age of precision medicine, and an understanding of the microbiome's influence on immune responses and cancer is key. It is also important to understand factors influencing the gut microbiome and strategies to manipulate the microbiome to augment therapeutic responses.
KW - cancer
KW - cancer immunosurveillance
KW - gut microbiome
KW - immunity
KW - immunotherapy
KW - immunotherapy response
KW - immunotherapy toxicity
KW - microbiome
KW - microbiome manipulation
KW - microbiota
UR - http://www.scopus.com/inward/record.url?scp=85044739809&partnerID=8YFLogxK
U2 - 10.1016/j.ccell.2018.03.015
DO - 10.1016/j.ccell.2018.03.015
M3 - Review article
C2 - 29634945
AN - SCOPUS:85044739809
VL - 33
SP - 570
EP - 580
JO - Cancer Cell
JF - Cancer Cell
SN - 1535-6108
IS - 4
ER -