TY - JOUR
T1 - The influence of receptor positioning on chemotactic information
AU - Nguyen, H.
AU - Dayan, P.
AU - Goodhill, G. J.
N1 - Funding Information:
Funding comes from an Australian Postgraduate Research Scholarship (H.N.), the Gatsby Charitable Foundation (P.D.) and Australian Research Council grant DP110101803 (G.J.G).
PY - 2014/11/7
Y1 - 2014/11/7
N2 - Chemotaxis, or gradient following, is important in many biological systems, but suffers from noise. How receptors are positioned on the cell or sensing device influences the quality of the inferences they can support about the gradient, suggesting that their configuration might be optimised. We show that for an elliptical sensing device, inhomogeneous receptor placement could be a potential approach for cells to eliminate bias in the posterior distribution of the gradient direction. We use information theory to calculate the mutual information between the gradient and the binding pattern, thus finding the optimal receptor arrangement for gradient sensing.
AB - Chemotaxis, or gradient following, is important in many biological systems, but suffers from noise. How receptors are positioned on the cell or sensing device influences the quality of the inferences they can support about the gradient, suggesting that their configuration might be optimised. We show that for an elliptical sensing device, inhomogeneous receptor placement could be a potential approach for cells to eliminate bias in the posterior distribution of the gradient direction. We use information theory to calculate the mutual information between the gradient and the binding pattern, thus finding the optimal receptor arrangement for gradient sensing.
KW - Bayesian inference
KW - Chemotaxis
KW - Information theory
KW - Statistical inference
UR - http://www.scopus.com/inward/record.url?scp=84904513191&partnerID=8YFLogxK
U2 - 10.1016/j.jtbi.2014.06.022
DO - 10.1016/j.jtbi.2014.06.022
M3 - Article
C2 - 24997237
AN - SCOPUS:84904513191
SN - 0022-5193
VL - 360
SP - 95
EP - 101
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
ER -