TY - JOUR
T1 - The influence of ischemia upon the energy reserves of inner ear tissues
AU - Thalmann, R.
AU - Miyoshi, T.
AU - Thalmann, I.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1972/12
Y1 - 1972/12
N2 - Ischemic changes in the levels of glucose, glycogen, ATP and P-creatine are determined under "closed system" conditions in the organ of Corti, stria vascularis, ganglion spirale, cochlear nerve and vestibular sensory epithelia. From the resting levels of these compounds the total energy reserve in terms of equivalents of high energy phosphate, both preformed and potentially available from anaerobic glycolysis, is computed. The energy reserves are highest in the organ of Corti, intermediate in stria vascularis, spiral ganglion and vestibular structures, and lowest in the cochlear nerve. The rate of depletion of these energy reserves in ischemia is used as an indicator of the energy requirements of the respective tissues. The metabolic rate is by far the highest in the stria vascularis, intermediate in ganglion spirale and cochlear nerve and lowest in the organ of Corti and vestibular structures. There is no correlation between the total energy reserve and the initial energy use rates. The obtained data are compared with the dynamic patterns of the corresponding biopotentials and with pertinent results of enzymatic and respirometric studies; in addition, ischemic changes in glucose and lactate levels of perilymph are described.
AB - Ischemic changes in the levels of glucose, glycogen, ATP and P-creatine are determined under "closed system" conditions in the organ of Corti, stria vascularis, ganglion spirale, cochlear nerve and vestibular sensory epithelia. From the resting levels of these compounds the total energy reserve in terms of equivalents of high energy phosphate, both preformed and potentially available from anaerobic glycolysis, is computed. The energy reserves are highest in the organ of Corti, intermediate in stria vascularis, spiral ganglion and vestibular structures, and lowest in the cochlear nerve. The rate of depletion of these energy reserves in ischemia is used as an indicator of the energy requirements of the respective tissues. The metabolic rate is by far the highest in the stria vascularis, intermediate in ganglion spirale and cochlear nerve and lowest in the organ of Corti and vestibular structures. There is no correlation between the total energy reserve and the initial energy use rates. The obtained data are compared with the dynamic patterns of the corresponding biopotentials and with pertinent results of enzymatic and respirometric studies; in addition, ischemic changes in glucose and lactate levels of perilymph are described.
UR - http://www.scopus.com/inward/record.url?scp=0015453317&partnerID=8YFLogxK
U2 - 10.1288/00005537-197212000-00013
DO - 10.1288/00005537-197212000-00013
M3 - Article
C2 - 4539701
AN - SCOPUS:0015453317
SN - 0023-852X
VL - 82
SP - 2249
EP - 2272
JO - Laryngoscope
JF - Laryngoscope
IS - 12
ER -