TY - JOUR
T1 - The increasing incidence of the hemolytic-uremic syndrome in king county, washington
T2 - Lack of evidence for ascertainment bias
AU - Tarr, Phillip I.
AU - Neill, Marguerite A.
AU - Allen, Jill
AU - Siccardi, Carole J.
AU - Watkins, Sandra L.
AU - Hickman, Robert O.
N1 - Funding Information:
Supported by Biomedical Research support grant S07RR05655 from the Division of Research Resources and training grant T32HD07233 from the National Institute of Child Health and Human Development.
PY - 1989/3
Y1 - 1989/3
N2 - The annual incidence of the hemolytic-uremic syndrome was determined for the well-defined population of King County, Washington, between 1971 and 1986, inclusive, to ascertain temporal trends in the epidemiology of this disease. The average annual incidence rose from 0.69 cases per 100,000 children under age 15 years between 1971 and 1975 to 1.77 cases between 1976 and 1980 and 1.74 cases between 1981 and 1986. The mean hematocrits, platelet counts, and blood urea nitrogen and creatinine concentrations on admission were similar in all periods, as were the mean length of hospital stay and the proportions of patients requiring erythrocyte and/or platelet transfusions and dialysis. These results indicate that the increased incidence of hemolytic-uremlc syndrome in childhood has been sustained in King County, Washington, and that this increase is not due to ascertainment bias caused by the diagnosis of less severely III cases. Further investigations are needed to determine whether this increased incidence is being experienced in other populations arid to assess strategies for the prevention of microangiopathic sequelae to hemorrhagic colitis.
AB - The annual incidence of the hemolytic-uremic syndrome was determined for the well-defined population of King County, Washington, between 1971 and 1986, inclusive, to ascertain temporal trends in the epidemiology of this disease. The average annual incidence rose from 0.69 cases per 100,000 children under age 15 years between 1971 and 1975 to 1.77 cases between 1976 and 1980 and 1.74 cases between 1981 and 1986. The mean hematocrits, platelet counts, and blood urea nitrogen and creatinine concentrations on admission were similar in all periods, as were the mean length of hospital stay and the proportions of patients requiring erythrocyte and/or platelet transfusions and dialysis. These results indicate that the increased incidence of hemolytic-uremlc syndrome in childhood has been sustained in King County, Washington, and that this increase is not due to ascertainment bias caused by the diagnosis of less severely III cases. Further investigations are needed to determine whether this increased incidence is being experienced in other populations arid to assess strategies for the prevention of microangiopathic sequelae to hemorrhagic colitis.
KW - Colitis
KW - Cytotoxins
KW - Escherichia coli
KW - Hemolytic-uremic syndrome
KW - Kidney failure, acute
KW - Toxins
UR - http://www.scopus.com/inward/record.url?scp=0024533660&partnerID=8YFLogxK
U2 - 10.1093/oxfordjournals.aje.a115170
DO - 10.1093/oxfordjournals.aje.a115170
M3 - Article
C2 - 2916551
AN - SCOPUS:0024533660
SN - 0002-9262
VL - 129
SP - 582
EP - 586
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 3
ER -