The Impact of Universal Glove and Gown Use on Clostridioides Difficile Acquisition: A Cluster-Randomized Trial

Daniel J. Morgan, Erik R. Dubberke, Tiffany Hink, Gwen Paszkiewicz, Carey Ann D. Burnham, Lisa Pineles, Larry Magder, J. Kristie Johnson, Surbhi Leekha, Anthony D. Harris

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: Clostridioides difficile is the most common cause of healthcare-Associated infections in the United States. It is unknown whether universal gown and glove use in intensive care units (ICUs) decreases acquisition of C. difficile. Methods: This was a secondary analysis of a cluster-randomized trial in 20 medical and surgical ICUs in 20 US hospitals from 4 January 2012 to 4 October 2012. After a baseline period, ICUs were randomized to standard practice for glove and gown use versus the intervention of all healthcare workers being required to wear gloves and gowns for all patient contact and when entering any patient room (contact precautions). The primary outcome was acquisition of toxigenic C. difficile determined by surveillance cultures collected on admission and discharge from the ICU. Results: A total of 21 845 patients had both admission and discharge perianal swabs cultured for toxigenic C. difficile. On admission, 9.43% (2060/21 845) of patients were colonized with toxigenic C. difficile. No significant difference was observed in the rate of toxigenic C. difficile acquisition with universal gown and glove use. Differences in acquisition rates in the study period compared with the baseline period in control ICUs were 1.49 per 100 patient-days versus 1.68 per 100 patient-days in universal gown and glove ICUs (rate difference,-0.28; generalized linear mixed model, P =. 091). Conclusions: Glove and gown use for all patient contact in medical and surgical ICUs did not result in a reduction in the acquisition of C. difficile compared with usual care. Clinical Trials Registration: NCT01318213.

Original languageEnglish
Pages (from-to)E1202-E1207
JournalClinical Infectious Diseases
Volume76
Issue number3
DOIs
StatePublished - Feb 1 2023

Keywords

  • Clostridioides difficile
  • antibiotic-resistance
  • barrier precautions
  • contact precautions

Fingerprint

Dive into the research topics of 'The Impact of Universal Glove and Gown Use on Clostridioides Difficile Acquisition: A Cluster-Randomized Trial'. Together they form a unique fingerprint.

Cite this