The Impact of Stress, Microbial Dysbiosis, and Inflammation on Necrotizing Enterocolitis

Venkata Yeramilli, Riadh Cheddadi, Heather Benjamin, Colin Martin

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Necrotizing enterocolitis (NEC) is the leading cause of intestinal morbidity and mortality in neonates. A large body of work exists; however, the pathogenesis of NEC remains poorly understood. Numerous predictors have been implicated in the development of NEC, with relatively less emphasis on maternal factors. Utilizing human tissue plays a crucial role in enhancing our comprehension of the underlying mechanisms accountable for this devastating disease. In this review, we will discuss how maternal stress affects the pathogenesis of NEC and how changes in the intestinal microbiome can influence the development of NEC. We will also discuss the results of transcriptomics-based studies and analyze the gene expression changes in NEC tissues and other molecular targets associated with the pathogenesis of NEC.

Original languageEnglish
Article number2206
Issue number9
StatePublished - Sep 2023


  • cortisol
  • inflammation
  • microbiome
  • necrotizing enterocolitis
  • prenatal stress


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