The impact of single-dose diethylcarbamazine treatment of bancroftian filariasis in a low-endemicity setting in Egypt

Reda M.R. Ramzy, Maged El Setouhy, Hanan Helmy, Amr M. Kandil, Ehab S. Ahmed, Hoda A. Farid, Rifky Faris, Gary J. Weil

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17 Scopus citations

Abstract

This study was designed to evaluate the effect of a single dose of diethylcarbamazine (DEC, 6 mg/kg) on Wuchereria bancrofti infections in a low-endemicity setting in Egypt (microfilaremia, or MF, 3.7%, median MF 34/mL). Subjects with MF or filarial antigenemia were treated and restudied 1 year later. Treatment with DEC dramatically reduced blood MF counts, with clearance in 69% of subjects. Treatment also reduced filarial antigen levels, but low clearance rates suggest that some adult worms survived treatment in most patients. Mass treatment was administered in one village; 27 months later, MF prevalence had decreased 84% (from 4.9% to 0.8%). These results show that single-dose DEC treatment can have a major effect on MF prevalence rates and levels in low-endemicity settings. Although the World Health Organization advocates repeated multidrug regimens for filariasis elimination, mass treatment with DEC alone may be sufficient to interrupt transmission in areas with low infection intensities and prevalence rates.

Original languageEnglish
Pages (from-to)196-200
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume67
Issue number2 SUPPL.
DOIs
StatePublished - Aug 1 2002

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