TY - JOUR
T1 - The impact of maternal stress on the development of necrotizing enterocolitis
T2 - A comprehensive review
AU - Cheddadi, Riadh
AU - Khandekar, Nitika Narendra
AU - Yeramilli, Venkata
AU - Martin, Colin
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/6
Y1 - 2023/6
N2 - Necrotizing Enterocolitis (NEC) is a devastating intestinal inflammatory disease with significant morbidity and mortality. Numerous predictors have been implicated in the development of NEC, with a relatively less emphasis on maternal factors. Pregnancy drives women into a new stage of life that increases their susceptibility to biological and psychological stress. Additionally, maternal stress during pregnancy has been linked to various complications that can negatively impact both the mother and the developing fetus. These detrimental effects are facilitated by various systemic modifications. Similarly, there is evidence from animal studies that suggest a relationship between maternal stress and the occurrence of NEC due to the alterations observed in neonates. In this review, we will (1) discuss the physiological and psychological burden of maternal stress and how it can be linked to NEC, (2) summarize various predictors and risk factors of NEC, and (3) discuss the most widely utilized animal models for assessing the effects of prenatal stress on offspring.
AB - Necrotizing Enterocolitis (NEC) is a devastating intestinal inflammatory disease with significant morbidity and mortality. Numerous predictors have been implicated in the development of NEC, with a relatively less emphasis on maternal factors. Pregnancy drives women into a new stage of life that increases their susceptibility to biological and psychological stress. Additionally, maternal stress during pregnancy has been linked to various complications that can negatively impact both the mother and the developing fetus. These detrimental effects are facilitated by various systemic modifications. Similarly, there is evidence from animal studies that suggest a relationship between maternal stress and the occurrence of NEC due to the alterations observed in neonates. In this review, we will (1) discuss the physiological and psychological burden of maternal stress and how it can be linked to NEC, (2) summarize various predictors and risk factors of NEC, and (3) discuss the most widely utilized animal models for assessing the effects of prenatal stress on offspring.
KW - Cortisol
KW - Necrotizing enterocolitis
KW - Pregnancy
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=85161763916&partnerID=8YFLogxK
U2 - 10.1016/j.sempedsurg.2023.151324
DO - 10.1016/j.sempedsurg.2023.151324
M3 - Review article
C2 - 37316382
AN - SCOPUS:85161763916
SN - 1055-8586
VL - 32
JO - Seminars in pediatric surgery
JF - Seminars in pediatric surgery
IS - 3
M1 - 151324
ER -