The Impact of Defective Viruses on Infection and Immunity

Emmanuelle Genoyer; Carolina B. López

doi:10.1146/annurev-virology-092818-015652

The Impact of Defective Viruses on Infection and Immunity

Emmanuelle Genoyer, Carolina B. López

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Defective viral genomes (DVGs) are generated during viral replication and are unable to carry out a full replication cycle unless coinfected with a full-length virus. DVGs are produced by many viruses, and their presence correlates with alterations in infection outcomes. Historically, DVGs were studied for their ability to interfere with standard virus replication as well as for their association with viral persistence. More recently, a critical role for DVGs in inducing the innate immune response during infection was appreciated. Here we review the role of DVGs of RNA viruses in shaping outcomes of experimental as well as natural infections and explore the mechanisms by which DVGs impact infection outcome.

Original language	English
Pages (from-to)	547-566
Number of pages	20
Journal	Annual Review of Virology
Volume	6
DOIs	https://doi.org/10.1146/annurev-virology-092818-015652
State	Published - Sep 29 2019

Keywords

antiviral immunity
defective interfering particles
defective viral genomes
defective virus
viral interference

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10.1146/annurev-virology-092818-015652

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title = "The Impact of Defective Viruses on Infection and Immunity",

abstract = "Defective viral genomes (DVGs) are generated during viral replication and are unable to carry out a full replication cycle unless coinfected with a full-length virus. DVGs are produced by many viruses, and their presence correlates with alterations in infection outcomes. Historically, DVGs were studied for their ability to interfere with standard virus replication as well as for their association with viral persistence. More recently, a critical role for DVGs in inducing the innate immune response during infection was appreciated. Here we review the role of DVGs of RNA viruses in shaping outcomes of experimental as well as natural infections and explore the mechanisms by which DVGs impact infection outcome.",

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AU - López, Carolina B.

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N2 - Defective viral genomes (DVGs) are generated during viral replication and are unable to carry out a full replication cycle unless coinfected with a full-length virus. DVGs are produced by many viruses, and their presence correlates with alterations in infection outcomes. Historically, DVGs were studied for their ability to interfere with standard virus replication as well as for their association with viral persistence. More recently, a critical role for DVGs in inducing the innate immune response during infection was appreciated. Here we review the role of DVGs of RNA viruses in shaping outcomes of experimental as well as natural infections and explore the mechanisms by which DVGs impact infection outcome.

AB - Defective viral genomes (DVGs) are generated during viral replication and are unable to carry out a full replication cycle unless coinfected with a full-length virus. DVGs are produced by many viruses, and their presence correlates with alterations in infection outcomes. Historically, DVGs were studied for their ability to interfere with standard virus replication as well as for their association with viral persistence. More recently, a critical role for DVGs in inducing the innate immune response during infection was appreciated. Here we review the role of DVGs of RNA viruses in shaping outcomes of experimental as well as natural infections and explore the mechanisms by which DVGs impact infection outcome.

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KW - defective interfering particles

KW - defective viral genomes

KW - defective virus

KW - viral interference

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ER -

The Impact of Defective Viruses on Infection and Immunity

Abstract

Keywords

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