TY - JOUR
T1 - The impact of alcohol consumption on the risk of cancer among men
T2 - A 20-year follow-up study from Finland
AU - Toriola, Adetunji T.
AU - Kurl, Sudhir
AU - Dyba, Tadeusz
AU - Laukkanen, Jari A.
AU - Kauhanen, Jussi
N1 - Funding Information:
We thank Kimmo Ronkainen of the Research Institute of Public Health, University of Kuopio/University of Eastern Finland, Finland, for data management. This study was supported by Grants 118551 and 118584 awarded by the Academy of Finland .
PY - 2010/6
Y1 - 2010/6
N2 - Introduction: Alcohol consumption is associated with certain cancer types and cancer deaths but there is paucity of information on the relationship between alcohol and total cancer risk. Hence, we examined this association. Methods: We analysed data from a prospective population-based cohort study of 2627 men from Eastern Finland who had no history of cancer at baseline. There were 515 incident cancer cases accrued over 52,540 person years during the 20 years of follow-up. Results: We observed a linear relationship between alcohol consumption and cancer. Men within the highest quintile of alcohol consumption (>115 g/week) had a 42% increased risk of total cancer compared with those within the lowest quintile (relative risk (RR) 1.42, 95% confidence interval (CI) 1.07-1.88; Ptrend = 0.03) after adjusting for age, smoking, total energy intake and cardio-respiratory fitness. The results were the same after excluding cancer cases diagnosed during the first 2 years of follow-up. Men who consumed ≥28.2 g/day of alcohol (median) had a relative risk of 1.22, 95% CI 1.03-1.46; P-value 0.03) compared to those who consumed less. Conclusion: About 6.7% of the cancer cases in this cohort were due to alcohol consumption. Strategies to reduce cancer burden need to incorporate reduction in alcohol consumption, probably beyond the level currently recommended.
AB - Introduction: Alcohol consumption is associated with certain cancer types and cancer deaths but there is paucity of information on the relationship between alcohol and total cancer risk. Hence, we examined this association. Methods: We analysed data from a prospective population-based cohort study of 2627 men from Eastern Finland who had no history of cancer at baseline. There were 515 incident cancer cases accrued over 52,540 person years during the 20 years of follow-up. Results: We observed a linear relationship between alcohol consumption and cancer. Men within the highest quintile of alcohol consumption (>115 g/week) had a 42% increased risk of total cancer compared with those within the lowest quintile (relative risk (RR) 1.42, 95% confidence interval (CI) 1.07-1.88; Ptrend = 0.03) after adjusting for age, smoking, total energy intake and cardio-respiratory fitness. The results were the same after excluding cancer cases diagnosed during the first 2 years of follow-up. Men who consumed ≥28.2 g/day of alcohol (median) had a relative risk of 1.22, 95% CI 1.03-1.46; P-value 0.03) compared to those who consumed less. Conclusion: About 6.7% of the cancer cases in this cohort were due to alcohol consumption. Strategies to reduce cancer burden need to incorporate reduction in alcohol consumption, probably beyond the level currently recommended.
KW - Alcohol
KW - Cancer
KW - Cardio-respiratory fitness
KW - Cohort study
KW - Energy intake
KW - Population-attributable fraction
KW - Population-based
UR - http://www.scopus.com/inward/record.url?scp=77952584202&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2010.03.035
DO - 10.1016/j.ejca.2010.03.035
M3 - Article
C2 - 20444594
AN - SCOPUS:77952584202
SN - 0959-8049
VL - 46
SP - 1488
EP - 1492
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 9
ER -