The impact of 6 weeks of atrial fibrillation on left atrial and ventricular structure and function

Toshinobu Kazui, Mathew C. Henn, Yoshiyuki Watanabe, Sándor J. Kovács, Christopher P. Lawrance, Jason W. Greenberg, Marc Moon, Richard B. Schuessler, Ralph J. Damiano

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Objective The impact of prolonged episodes of atrial fibrillation on atrial and ventricular function has been incompletely characterized. The purpose of this study was to investigate the influence of atrial fibrillation on left atrial and ventricular function in a rapid paced porcine model of atrial fibrillation. Methods A control group of pigs (group 1, n = 8) underwent left atrial and left ventricular conductance catheter studies and fibrosis analysis. A second group (group 2, n = 8) received a baseline cardiac magnetic resonance imaging to characterize left atrial and left ventricular function. The atria were rapidly paced into atrial fibrillation for 6 weeks followed by cardioversion and cardiac magnetic resonance imaging. Results After 6 weeks of atrial fibrillation, left atrial contractility defined by atrial end-systolic pressure-volume relationship slope was significantly lower in group 2 than in group 1 (1.1 ± 0.5 vs 1.7 ± 1.0; P =.041), whereas compliance from the end-diastolic pressure-volume relationship was unchanged (1.5 ± 0.9 vs 1.6 ± 1.3; P =.733). Compared with baseline, atrial fibrillation resulted in a significantly higher contribution of left atrial reservoir volume to stroke volume (32% vs 17%; P =.005) and lower left atrial booster pump volume contribution to stroke volume (19% vs 28%; P =.029). Atrial fibrillation also significantly increased maximum left atrial volume (206 ± 41 mL vs 90 ± 21 mL; P <.001). Left atrial fibrosis in group 2 was significantly higher than in group 1. Atrial fibrillation decreased left ventricular ejection fraction (29% ± 9% vs 58 ± 8%; P <.001), but left ventricular stroke volume was unchanged. Conclusions In a chronic model of atrial fibrillation, the left atrium demonstrated significant structural remodeling and decreased contractility. These data suggest that early intervention in patients with persistent atrial fibrillation might mitigate against adverse atrial and ventricular structural remodeling.

Original languageEnglish
Pages (from-to)1602-1608.e1
JournalJournal of Thoracic and Cardiovascular Surgery
Volume150
Issue number6
DOIs
StatePublished - Dec 2015

Keywords

  • Cox-Maze
  • atrial fibrillation
  • atrial function

Fingerprint Dive into the research topics of 'The impact of 6 weeks of atrial fibrillation on left atrial and ventricular structure and function'. Together they form a unique fingerprint.

Cite this