109 Scopus citations

Abstract

This review explores the principle features of the immunopathology of multiple sclerosis (MS), particularly relapsing-remitting MS. It highlights the emerging concepts in the pathogenesis of MS in the context of known features of pathology, including the characterization of cytokine networks promoting inflammatory damage of the central nervous system, B-cell involvement, and inflammatory damage of axons and neurons. This article preferentially focuses on MS rather than animal models of the disease, such as experimental autoimmune encephalomyelitis.

Original languageEnglish
Pages (from-to)257-278
Number of pages22
JournalNeurologic Clinics
Volume29
Issue number2
DOIs
StatePublished - May 2011

Keywords

  • Demyelination
  • Multiple sclerosis
  • Neuroimmunology
  • Pathogenesis

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