The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

Kyeong Hee Lee; Aaron R. Dinner; Chun Tu; Gabriele Campi; Subhadip Raychaudhuri; Rajat Varma; Tasha N. Sims; W. Richard Burack; Hui Wu; Julia Wang; Osami Kanagawa; Mary Markiewicz; Paul M. Allen; Michael L. Dustin; Arup K. Chakraborty; Andrey S. Shaw

doi:10.1126/science.1086507

The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

Kyeong Hee Lee
, Aaron R. Dinner
, Chun Tu
, Gabriele Campi
, Subhadip Raychaudhuri
, Rajat Varma
, Tasha N. Sims
, W. Richard Burack
, Hui Wu
, Julia Wang
, Osami Kanagawa
, Mary Markiewicz
, Paul M. Allen
, Michael L. Dustin
, Arup K. Chakraborty
, Andrey S. Shaw

Research output: Contribution to journal › Article › peer-review

478 Scopus citations

Abstract

The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.

Original language	English
Pages (from-to)	1218-1222
Number of pages	5
Journal	Science
Volume	302
Issue number	5648
DOIs	https://doi.org/10.1126/science.1086507
State	Published - Nov 14 2003

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10.1126/science.1086507

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Lee, K. H., Dinner, A. R., Tu, C., Campi, G., Raychaudhuri, S., Varma, R., Sims, T. N., Burack, W. R., Wu, H., Wang, J., Kanagawa, O., Markiewicz, M., Allen, P. M., Dustin, M. L., Chakraborty, A. K., & Shaw, A. S. (2003). The Immunological Synapse Balances T Cell Receptor Signaling and Degradation. Science, 302(5648), 1218-1222. https://doi.org/10.1126/science.1086507

@article{383c8918e306429b98b08e79023efcfc,

title = "The Immunological Synapse Balances T Cell Receptor Signaling and Degradation",

abstract = "The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.",

author = "Lee, \{Kyeong Hee\} and Dinner, \{Aaron R.\} and Chun Tu and Gabriele Campi and Subhadip Raychaudhuri and Rajat Varma and Sims, \{Tasha N.\} and Burack, \{W. Richard\} and Hui Wu and Julia Wang and Osami Kanagawa and Mary Markiewicz and Allen, \{Paul M.\} and Dustin, \{Michael L.\} and Chakraborty, \{Arup K.\} and Shaw, \{Andrey S.\}",

year = "2003",

month = nov,

day = "14",

doi = "10.1126/science.1086507",

language = "English",

volume = "302",

pages = "1218--1222",

journal = "Science",

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T1 - The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

AU - Lee, Kyeong Hee

AU - Dinner, Aaron R.

AU - Tu, Chun

AU - Campi, Gabriele

AU - Raychaudhuri, Subhadip

AU - Varma, Rajat

AU - Sims, Tasha N.

AU - Burack, W. Richard

AU - Wu, Hui

AU - Wang, Julia

AU - Kanagawa, Osami

AU - Markiewicz, Mary

AU - Allen, Paul M.

AU - Dustin, Michael L.

AU - Chakraborty, Arup K.

AU - Shaw, Andrey S.

PY - 2003/11/14

Y1 - 2003/11/14

N2 - The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.

AB - The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.

UR - https://www.scopus.com/pages/publications/0242497659

U2 - 10.1126/science.1086507

DO - 10.1126/science.1086507

M3 - Article

C2 - 14512504

AN - SCOPUS:0242497659

SN - 0036-8075

VL - 302

SP - 1218

EP - 1222

JO - Science

JF - Science

IS - 5648

ER -

The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

Abstract

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