The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

Kyeong Hee Lee, Aaron R. Dinner, Chun Tu, Gabriele Campi, Subhadip Raychaudhuri, Rajat Varma, Tasha N. Sims, W. Richard Burack, Hui Wu, Julia Wang, Osami Kanagawa, Mary Markiewicz, Paul M. Allen, Michael L. Dustin, Arup K. Chakraborty, Andrey S. Shaw

Research output: Contribution to journalArticle

437 Scopus citations

Abstract

The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.

Original languageEnglish
Pages (from-to)1218-1222
Number of pages5
JournalScience
Volume302
Issue number5648
DOIs
StatePublished - Nov 14 2003

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    Lee, K. H., Dinner, A. R., Tu, C., Campi, G., Raychaudhuri, S., Varma, R., Sims, T. N., Burack, W. R., Wu, H., Wang, J., Kanagawa, O., Markiewicz, M., Allen, P. M., Dustin, M. L., Chakraborty, A. K., & Shaw, A. S. (2003). The Immunological Synapse Balances T Cell Receptor Signaling and Degradation. Science, 302(5648), 1218-1222. https://doi.org/10.1126/science.1086507