TY - JOUR
T1 - The immunobiology of cancer immunosurveillance and immunoediting
AU - Dunn, Gavin P.
AU - Old, Lloyd J.
AU - Schreiber, Robert D.
N1 - Funding Information:
The authors are grateful to Drs. Ravindra Uppaluri and Jack Bui of Washington University School of Medicine for helpful comments during the preparation of this manuscript. Work in the authors' laboratories quoted in this review was supported by grants from the National Cancer Institute, the Ludwig Institute for Cancer Research and the Cancer Research Institute.
PY - 2004/8
Y1 - 2004/8
N2 - The last fifteen years have seen a reemergence of interest in cancer immunosurveillance and a broadening of this concept into one termed cancer immunoediting. The latter, supported by strong experimental data derived from murine tumor models and provocative correlative data obtained by studying human cancer, holds that the immune system not only protects the host against development of primary nonviral cancers but also sculpts tumor immunogenicity. Cancer immunoediting is a process consisting of three phases: elimination (i.e., cancer immunosurveillance), equilibrium, and escape. Herein, we summarize the data supporting the existence of each of the three cancer immunoediting phases. The full understanding of the immunobiology of cancer immunosurveillance and immunoediting will hopefully stimulate development of more effective immunotherapeutic approaches to control and/or eliminate human cancers.
AB - The last fifteen years have seen a reemergence of interest in cancer immunosurveillance and a broadening of this concept into one termed cancer immunoediting. The latter, supported by strong experimental data derived from murine tumor models and provocative correlative data obtained by studying human cancer, holds that the immune system not only protects the host against development of primary nonviral cancers but also sculpts tumor immunogenicity. Cancer immunoediting is a process consisting of three phases: elimination (i.e., cancer immunosurveillance), equilibrium, and escape. Herein, we summarize the data supporting the existence of each of the three cancer immunoediting phases. The full understanding of the immunobiology of cancer immunosurveillance and immunoediting will hopefully stimulate development of more effective immunotherapeutic approaches to control and/or eliminate human cancers.
UR - http://www.scopus.com/inward/record.url?scp=4143141823&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2004.07.017
DO - 10.1016/j.immuni.2004.07.017
M3 - Review article
C2 - 15308095
AN - SCOPUS:4143141823
SN - 1074-7613
VL - 21
SP - 137
EP - 148
JO - Immunity
JF - Immunity
IS - 2
ER -