The immune system and the histiocytosis syndromes

M. E. Nesbit, M. O'Leary, L. P. Dehner, N. K.C. Ramsay

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


The histiocytosis syndromes consist of a heterogeneous group of disorders referred to as histiocytosis X or differentiated histiocytosis. Although a large proportion of cases of histiocytosis remains to be of an idiopathic nature, there are cases in which the etiologic mechanism appears to be a defect in the immune system. Provided is a brief of the literature regarding the immune system in histiocytic disease and a review of the experience at the University of Minnesota with immunologic evaluation of children with histiocytic reactions. Two general hypotheses on the relationship between the immune system and histiocytosis syndromes are discussed.

Original languageEnglish
Pages (from-to)141-149
Number of pages9
JournalAmerican Journal of Pediatric Hematology/Oncology
Issue number2
StatePublished - 1981


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