The immune landscape in tuberculosis reveals populations linked to disease and latency

Ekaterina Esaulova; Shibali Das; Dhiraj Kumar Singh; Jose Alberto Choreño-Parra; Amanda Swain; Laura Arthur; Javier Rangel-Moreno; Mushtaq Ahmed; Bindu Singh; Ananya Gupta; Luis Alejandro Fernández-López; Maria de la Luz Garcia-Hernandez; Allison Bucsan; Chivonne Moodley; Smriti Mehra; Ethel García-Latorre; Joaquin Zuniga; Jeffrey Atkinson; Deepak Kaushal; Maxim N. Artyomov; Shabaana A. Khader

doi:10.1016/j.chom.2020.11.013

The immune landscape in tuberculosis reveals populations linked to disease and latency

Ekaterina Esaulova, Shibali Das, Dhiraj Kumar Singh, Jose Alberto Choreño-Parra, Amanda Swain, Laura Arthur, Javier Rangel-Moreno, Mushtaq Ahmed, Bindu Singh, Ananya Gupta, Luis Alejandro Fernández-López, Maria de la Luz Garcia-Hernandez, Allison Bucsan, Chivonne Moodley, Smriti Mehra, Ethel García-Latorre, Joaquin Zuniga, Jeffrey Atkinson, Deepak Kaushal, Maxim N. ArtyomovShabaana A. Khader

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39 Scopus citations

Abstract

Esaulova, Das, Singh et al. characterize the lung landscape during tuberculosis disease and control using single cell and conventional technologies. Their results delineate NK cells as a feature of protection during latency, and the presence of pDCs, IFN-responsive macrophages and activated T cells as a feature of disease.

Original language	English
Pages (from-to)	165-178.e8
Journal	Cell Host and Microbe
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/j.chom.2020.11.013
State	Published - Feb 10 2021

Keywords

NK cells
granulomas
immune protection
lung
pDCs
single cell technologies
tuberculosis
type I IFNs

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10.1016/j.chom.2020.11.013

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Esaulova, E., Das, S., Singh, D. K., Choreño-Parra, J. A., Swain, A., Arthur, L., Rangel-Moreno, J., Ahmed, M., Singh, B., Gupta, A., Fernández-López, L. A., de la Luz Garcia-Hernandez, M., Bucsan, A., Moodley, C., Mehra, S., García-Latorre, E., Zuniga, J., Atkinson, J., Kaushal, D., ... Khader, S. A. (2021). The immune landscape in tuberculosis reveals populations linked to disease and latency. Cell Host and Microbe, 29(2), 165-178.e8. https://doi.org/10.1016/j.chom.2020.11.013

@article{475ee541834846f9b8534a7290d3bdf5,

title = "The immune landscape in tuberculosis reveals populations linked to disease and latency",

abstract = "Esaulova, Das, Singh et al. characterize the lung landscape during tuberculosis disease and control using single cell and conventional technologies. Their results delineate NK cells as a feature of protection during latency, and the presence of pDCs, IFN-responsive macrophages and activated T cells as a feature of disease.",

keywords = "NK cells, granulomas, immune protection, lung, pDCs, single cell technologies, tuberculosis, type I IFNs",

author = "Ekaterina Esaulova and Shibali Das and Singh, {Dhiraj Kumar} and Chore{\~n}o-Parra, {Jose Alberto} and Amanda Swain and Laura Arthur and Javier Rangel-Moreno and Mushtaq Ahmed and Bindu Singh and Ananya Gupta and Fern{\'a}ndez-L{\'o}pez, {Luis Alejandro} and {de la Luz Garcia-Hernandez}, Maria and Allison Bucsan and Chivonne Moodley and Smriti Mehra and Ethel Garc{\'i}a-Latorre and Joaquin Zuniga and Jeffrey Atkinson and Deepak Kaushal and Artyomov, {Maxim N.} and Khader, {Shabaana A.}",

note = "Funding Information: This work was supported by Washington University in St. Louis School of Medicine ; NIH grant HL105427 , AI111914-02 , AI134236-02 , R01AI155024 and AI123780 to S.A.K. and D.K.; and the Department of Molecular Microbiology, Washington University School of Medicine , and Stephen I. Morse Fellowship to S.D. E.E. was supported by Shawn Hu and Angela Zeng Graduate Fellowship . J.A.C.P was supported by the National Council of Science and Technology of Mexico (CONACyT, CVU 737347 ). J.R.-M. was supported by funds of the Department of Medicine, University of Rochester , and NIH grant U19 AI91036 . None of the authors have conflicts to report. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

month = feb,

day = "10",

doi = "10.1016/j.chom.2020.11.013",

language = "English",

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Esaulova, E, Das, S, Singh, DK, Choreño-Parra, JA, Swain, A, Arthur, L, Rangel-Moreno, J, Ahmed, M, Singh, B, Gupta, A, Fernández-López, LA, de la Luz Garcia-Hernandez, M, Bucsan, A, Moodley, C, Mehra, S, García-Latorre, E, Zuniga, J, Atkinson, J, Kaushal, D, Artyomov, MN & Khader, SA 2021, 'The immune landscape in tuberculosis reveals populations linked to disease and latency', Cell Host and Microbe, vol. 29, no. 2, pp. 165-178.e8. https://doi.org/10.1016/j.chom.2020.11.013

TY - JOUR

T1 - The immune landscape in tuberculosis reveals populations linked to disease and latency

AU - Esaulova, Ekaterina

AU - Das, Shibali

AU - Singh, Dhiraj Kumar

AU - Choreño-Parra, Jose Alberto

AU - Swain, Amanda

AU - Arthur, Laura

AU - Rangel-Moreno, Javier

AU - Ahmed, Mushtaq

AU - Singh, Bindu

AU - Gupta, Ananya

AU - Fernández-López, Luis Alejandro

AU - de la Luz Garcia-Hernandez, Maria

AU - Bucsan, Allison

AU - Moodley, Chivonne

AU - Mehra, Smriti

AU - García-Latorre, Ethel

AU - Zuniga, Joaquin

AU - Atkinson, Jeffrey

AU - Kaushal, Deepak

AU - Artyomov, Maxim N.

AU - Khader, Shabaana A.

N1 - Funding Information: This work was supported by Washington University in St. Louis School of Medicine ; NIH grant HL105427 , AI111914-02 , AI134236-02 , R01AI155024 and AI123780 to S.A.K. and D.K.; and the Department of Molecular Microbiology, Washington University School of Medicine , and Stephen I. Morse Fellowship to S.D. E.E. was supported by Shawn Hu and Angela Zeng Graduate Fellowship . J.A.C.P was supported by the National Council of Science and Technology of Mexico (CONACyT, CVU 737347 ). J.R.-M. was supported by funds of the Department of Medicine, University of Rochester , and NIH grant U19 AI91036 . None of the authors have conflicts to report. Publisher Copyright: © 2020 Elsevier Inc.

PY - 2021/2/10

Y1 - 2021/2/10

N2 - Esaulova, Das, Singh et al. characterize the lung landscape during tuberculosis disease and control using single cell and conventional technologies. Their results delineate NK cells as a feature of protection during latency, and the presence of pDCs, IFN-responsive macrophages and activated T cells as a feature of disease.

AB - Esaulova, Das, Singh et al. characterize the lung landscape during tuberculosis disease and control using single cell and conventional technologies. Their results delineate NK cells as a feature of protection during latency, and the presence of pDCs, IFN-responsive macrophages and activated T cells as a feature of disease.

KW - NK cells

KW - granulomas

KW - immune protection

KW - lung

KW - pDCs

KW - single cell technologies

KW - tuberculosis

KW - type I IFNs

UR - http://www.scopus.com/inward/record.url?scp=85099203176&partnerID=8YFLogxK

U2 - 10.1016/j.chom.2020.11.013

DO - 10.1016/j.chom.2020.11.013

M3 - Article

C2 - 33340449

AN - SCOPUS:85099203176

VL - 29

SP - 165-178.e8

JO - Cell Host and Microbe

JF - Cell Host and Microbe

SN - 1931-3128

IS - 2

ER -

The immune landscape in tuberculosis reveals populations linked to disease and latency

Abstract

Keywords

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