TY - JOUR
T1 - The immune landscape in tuberculosis reveals populations linked to disease and latency
AU - Esaulova, Ekaterina
AU - Das, Shibali
AU - Singh, Dhiraj Kumar
AU - Choreño-Parra, Jose Alberto
AU - Swain, Amanda
AU - Arthur, Laura
AU - Rangel-Moreno, Javier
AU - Ahmed, Mushtaq
AU - Singh, Bindu
AU - Gupta, Ananya
AU - Fernández-López, Luis Alejandro
AU - de la Luz Garcia-Hernandez, Maria
AU - Bucsan, Allison
AU - Moodley, Chivonne
AU - Mehra, Smriti
AU - García-Latorre, Ethel
AU - Zuniga, Joaquin
AU - Atkinson, Jeffrey
AU - Kaushal, Deepak
AU - Artyomov, Maxim N.
AU - Khader, Shabaana A.
N1 - Funding Information:
This work was supported by Washington University in St. Louis School of Medicine ; NIH grant HL105427 , AI111914-02 , AI134236-02 , R01AI155024 and AI123780 to S.A.K. and D.K.; and the Department of Molecular Microbiology, Washington University School of Medicine , and Stephen I. Morse Fellowship to S.D. E.E. was supported by Shawn Hu and Angela Zeng Graduate Fellowship . J.A.C.P was supported by the National Council of Science and Technology of Mexico (CONACyT, CVU 737347 ). J.R.-M. was supported by funds of the Department of Medicine, University of Rochester , and NIH grant U19 AI91036 . None of the authors have conflicts to report.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/2/10
Y1 - 2021/2/10
N2 - Esaulova, Das, Singh et al. characterize the lung landscape during tuberculosis disease and control using single cell and conventional technologies. Their results delineate NK cells as a feature of protection during latency, and the presence of pDCs, IFN-responsive macrophages and activated T cells as a feature of disease.
AB - Esaulova, Das, Singh et al. characterize the lung landscape during tuberculosis disease and control using single cell and conventional technologies. Their results delineate NK cells as a feature of protection during latency, and the presence of pDCs, IFN-responsive macrophages and activated T cells as a feature of disease.
KW - NK cells
KW - granulomas
KW - immune protection
KW - lung
KW - pDCs
KW - single cell technologies
KW - tuberculosis
KW - type I IFNs
UR - http://www.scopus.com/inward/record.url?scp=85099203176&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2020.11.013
DO - 10.1016/j.chom.2020.11.013
M3 - Article
C2 - 33340449
AN - SCOPUS:85099203176
VL - 29
SP - 165-178.e8
JO - Cell Host and Microbe
JF - Cell Host and Microbe
SN - 1931-3128
IS - 2
ER -