The immune landscape in tuberculosis reveals populations linked to disease and latency

Ekaterina Esaulova; Shibali Das; Dhiraj Kumar Singh; Jose Alberto Choreño-Parra; Amanda Swain; Laura Arthur; Javier Rangel-Moreno; Mushtaq Ahmed; Bindu Singh; Ananya Gupta; Luis Alejandro Fernández-López; Maria de la Luz Garcia-Hernandez; Allison Bucsan; Chivonne Moodley; Smriti Mehra; Ethel García-Latorre; Joaquin Zuniga; Jeffrey Atkinson; Deepak Kaushal; Maxim N. Artyomov; Shabaana A. Khader

doi:10.1016/j.chom.2020.11.013

The immune landscape in tuberculosis reveals populations linked to disease and latency

Ekaterina Esaulova, Shibali Das, Dhiraj Kumar Singh, Jose Alberto Choreño-Parra, Amanda Swain, Laura Arthur, Javier Rangel-Moreno, Mushtaq Ahmed, Bindu Singh, Ananya Gupta, Luis Alejandro Fernández-López, Maria de la Luz Garcia-Hernandez, Allison Bucsan, Chivonne Moodley, Smriti Mehra, Ethel García-Latorre, Joaquin Zuniga, Jeffrey Atkinson, Deepak Kaushal, Maxim N. ArtyomovShabaana A. Khader

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Esaulova, Das, Singh et al. characterize the lung landscape during tuberculosis disease and control using single cell and conventional technologies. Their results delineate NK cells as a feature of protection during latency, and the presence of pDCs, IFN-responsive macrophages and activated T cells as a feature of disease.

Original language	English
Pages (from-to)	165-178.e8
Journal	Cell Host and Microbe
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/j.chom.2020.11.013
State	Published - Feb 10 2021

Keywords

NK cells
granulomas
immune protection
lung
pDCs
single cell technologies
tuberculosis
type I IFNs

Access to Document

10.1016/j.chom.2020.11.013

Cite this

Esaulova, E., Das, S., Singh, D. K., Choreño-Parra, J. A., Swain, A., Arthur, L., Rangel-Moreno, J., Ahmed, M., Singh, B., Gupta, A., Fernández-López, L. A., de la Luz Garcia-Hernandez, M., Bucsan, A., Moodley, C., Mehra, S., García-Latorre, E., Zuniga, J., Atkinson, J., Kaushal, D., ... Khader, S. A. (2021). The immune landscape in tuberculosis reveals populations linked to disease and latency. Cell Host and Microbe, 29(2), 165-178.e8. https://doi.org/10.1016/j.chom.2020.11.013

Esaulova, Ekaterina ; Das, Shibali ; Singh, Dhiraj Kumar ; Choreño-Parra, Jose Alberto ; Swain, Amanda ; Arthur, Laura ; Rangel-Moreno, Javier ; Ahmed, Mushtaq ; Singh, Bindu ; Gupta, Ananya ; Fernández-López, Luis Alejandro ; de la Luz Garcia-Hernandez, Maria ; Bucsan, Allison ; Moodley, Chivonne ; Mehra, Smriti ; García-Latorre, Ethel ; Zuniga, Joaquin ; Atkinson, Jeffrey ; Kaushal, Deepak ; Artyomov, Maxim N. ; Khader, Shabaana A. / The immune landscape in tuberculosis reveals populations linked to disease and latency. In: Cell Host and Microbe. 2021 ; Vol. 29, No. 2. pp. 165-178.e8.

@article{475ee541834846f9b8534a7290d3bdf5,

title = "The immune landscape in tuberculosis reveals populations linked to disease and latency",

abstract = "Esaulova, Das, Singh et al. characterize the lung landscape during tuberculosis disease and control using single cell and conventional technologies. Their results delineate NK cells as a feature of protection during latency, and the presence of pDCs, IFN-responsive macrophages and activated T cells as a feature of disease.",

keywords = "NK cells, granulomas, immune protection, lung, pDCs, single cell technologies, tuberculosis, type I IFNs",

author = "Ekaterina Esaulova and Shibali Das and Singh, {Dhiraj Kumar} and Chore{\~n}o-Parra, {Jose Alberto} and Amanda Swain and Laura Arthur and Javier Rangel-Moreno and Mushtaq Ahmed and Bindu Singh and Ananya Gupta and Fern{\'a}ndez-L{\'o}pez, {Luis Alejandro} and {de la Luz Garcia-Hernandez}, Maria and Allison Bucsan and Chivonne Moodley and Smriti Mehra and Ethel Garc{\'i}a-Latorre and Joaquin Zuniga and Jeffrey Atkinson and Deepak Kaushal and Artyomov, {Maxim N.} and Khader, {Shabaana A.}",

note = "Funding Information: This work was supported by Washington University in St. Louis School of Medicine ; NIH grant HL105427 , AI111914-02 , AI134236-02 , R01AI155024 and AI123780 to S.A.K. and D.K.; and the Department of Molecular Microbiology, Washington University School of Medicine , and Stephen I. Morse Fellowship to S.D. E.E. was supported by Shawn Hu and Angela Zeng Graduate Fellowship . J.A.C.P was supported by the National Council of Science and Technology of Mexico (CONACyT, CVU 737347 ). J.R.-M. was supported by funds of the Department of Medicine, University of Rochester , and NIH grant U19 AI91036 . None of the authors have conflicts to report. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

month = feb,

day = "10",

doi = "10.1016/j.chom.2020.11.013",

language = "English",

volume = "29",

pages = "165--178.e8",

journal = "Cell Host and Microbe",

issn = "1931-3128",

number = "2",

}

Esaulova, E, Das, S, Singh, DK, Choreño-Parra, JA, Swain, A, Arthur, L, Rangel-Moreno, J, Ahmed, M, Singh, B, Gupta, A, Fernández-López, LA, de la Luz Garcia-Hernandez, M, Bucsan, A, Moodley, C, Mehra, S, García-Latorre, E, Zuniga, J, Atkinson, J, Kaushal, D, Artyomov, MN & Khader, SA 2021, 'The immune landscape in tuberculosis reveals populations linked to disease and latency', Cell Host and Microbe, vol. 29, no. 2, pp. 165-178.e8. https://doi.org/10.1016/j.chom.2020.11.013

The immune landscape in tuberculosis reveals populations linked to disease and latency. / Esaulova, Ekaterina; Das, Shibali; Singh, Dhiraj Kumar; Choreño-Parra, Jose Alberto; Swain, Amanda; Arthur, Laura; Rangel-Moreno, Javier; Ahmed, Mushtaq; Singh, Bindu; Gupta, Ananya; Fernández-López, Luis Alejandro; de la Luz Garcia-Hernandez, Maria; Bucsan, Allison; Moodley, Chivonne; Mehra, Smriti; García-Latorre, Ethel; Zuniga, Joaquin; Atkinson, Jeffrey; Kaushal, Deepak; Artyomov, Maxim N.; Khader, Shabaana A.

In: Cell Host and Microbe, Vol. 29, No. 2, 10.02.2021, p. 165-178.e8.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The immune landscape in tuberculosis reveals populations linked to disease and latency

AU - Esaulova, Ekaterina

AU - Das, Shibali

AU - Singh, Dhiraj Kumar

AU - Choreño-Parra, Jose Alberto

AU - Swain, Amanda

AU - Arthur, Laura

AU - Rangel-Moreno, Javier

AU - Ahmed, Mushtaq

AU - Singh, Bindu

AU - Gupta, Ananya

AU - Fernández-López, Luis Alejandro

AU - de la Luz Garcia-Hernandez, Maria

AU - Bucsan, Allison

AU - Moodley, Chivonne

AU - Mehra, Smriti

AU - García-Latorre, Ethel

AU - Zuniga, Joaquin

AU - Atkinson, Jeffrey

AU - Kaushal, Deepak

AU - Artyomov, Maxim N.

AU - Khader, Shabaana A.

N1 - Funding Information: This work was supported by Washington University in St. Louis School of Medicine ; NIH grant HL105427 , AI111914-02 , AI134236-02 , R01AI155024 and AI123780 to S.A.K. and D.K.; and the Department of Molecular Microbiology, Washington University School of Medicine , and Stephen I. Morse Fellowship to S.D. E.E. was supported by Shawn Hu and Angela Zeng Graduate Fellowship . J.A.C.P was supported by the National Council of Science and Technology of Mexico (CONACyT, CVU 737347 ). J.R.-M. was supported by funds of the Department of Medicine, University of Rochester , and NIH grant U19 AI91036 . None of the authors have conflicts to report. Publisher Copyright: © 2020 Elsevier Inc.

PY - 2021/2/10

Y1 - 2021/2/10

N2 - Esaulova, Das, Singh et al. characterize the lung landscape during tuberculosis disease and control using single cell and conventional technologies. Their results delineate NK cells as a feature of protection during latency, and the presence of pDCs, IFN-responsive macrophages and activated T cells as a feature of disease.

AB - Esaulova, Das, Singh et al. characterize the lung landscape during tuberculosis disease and control using single cell and conventional technologies. Their results delineate NK cells as a feature of protection during latency, and the presence of pDCs, IFN-responsive macrophages and activated T cells as a feature of disease.

KW - NK cells

KW - granulomas

KW - immune protection

KW - lung

KW - pDCs

KW - single cell technologies

KW - tuberculosis

KW - type I IFNs

UR - http://www.scopus.com/inward/record.url?scp=85099203176&partnerID=8YFLogxK

U2 - 10.1016/j.chom.2020.11.013

DO - 10.1016/j.chom.2020.11.013

M3 - Article

C2 - 33340449

AN - SCOPUS:85099203176

VL - 29

SP - 165-178.e8

JO - Cell Host and Microbe

JF - Cell Host and Microbe

SN - 1931-3128

IS - 2

ER -

The immune landscape in tuberculosis reveals populations linked to disease and latency

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this