The immune landscape in tuberculosis reveals populations linked to disease and latency

Ekaterina Esaulova, Shibali Das, Dhiraj Kumar Singh, Jose Alberto Choreño-Parra, Amanda Swain, Laura Arthur, Javier Rangel-Moreno, Mushtaq Ahmed, Bindu Singh, Ananya Gupta, Luis Alejandro Fernández-López, Maria de la Luz Garcia-Hernandez, Allison Bucsan, Chivonne Moodley, Smriti Mehra, Ethel García-Latorre, Joaquin Zuniga, Jeffrey Atkinson, Deepak Kaushal, Maxim N. ArtyomovShabaana A. Khader

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Esaulova, Das, Singh et al. characterize the lung landscape during tuberculosis disease and control using single cell and conventional technologies. Their results delineate NK cells as a feature of protection during latency, and the presence of pDCs, IFN-responsive macrophages and activated T cells as a feature of disease.

Original languageEnglish
Pages (from-to)165-178.e8
JournalCell Host and Microbe
Volume29
Issue number2
DOIs
StatePublished - Feb 10 2021

Keywords

  • NK cells
  • granulomas
  • immune protection
  • lung
  • pDCs
  • single cell technologies
  • tuberculosis
  • type I IFNs

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