The IFNγ receptor: A paradigm for cytokine receptor signaling

Erika A. Bach; Michel Aguet; Robert D. Schreiber

doi:10.1146/annurev.immunol.15.1.563

The IFNγ receptor: A paradigm for cytokine receptor signaling

Erika A. Bach, Michel Aguet, Robert D. Schreiber

Research output: Contribution to journal › Review article › peer-review

898 Scopus citations

Abstract

During the last several years, the mechanism of IFNγ-dependent signal transduction has been the focus of intense investigation. This research has recently culminated in the elucidation of a comprehensive molecular understanding of the events that underlie IFNγ-induced cellular responses. The structure and function of the IFNγ receptor have been defined. The mechanism of IFNγ signal transduction has been largely elucidated, and the physiologic relevance of this process validated. Most recently, the molecular events that link receptor ligation to signal transduction have been established. Together these insights have produced a model of IFNγ signaling that is nearly complete and that serves as a paradigm for signaling by other members of the cytokine receptor superfamily.

Original language	English
Pages (from-to)	563-591
Number of pages	29
Journal	Annual Review of Immunology
Volume	15
DOIs	https://doi.org/10.1146/annurev.immunol.15.1.563
State	Published - Apr 29 1997

Keywords

JAK-STAT pathway
Stat1
signal transduction
transcription factors
tyrosine kinases

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10.1146/annurev.immunol.15.1.563

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abstract = "During the last several years, the mechanism of IFNγ-dependent signal transduction has been the focus of intense investigation. This research has recently culminated in the elucidation of a comprehensive molecular understanding of the events that underlie IFNγ-induced cellular responses. The structure and function of the IFNγ receptor have been defined. The mechanism of IFNγ signal transduction has been largely elucidated, and the physiologic relevance of this process validated. Most recently, the molecular events that link receptor ligation to signal transduction have been established. Together these insights have produced a model of IFNγ signaling that is nearly complete and that serves as a paradigm for signaling by other members of the cytokine receptor superfamily.",

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AU - Aguet, Michel

AU - Schreiber, Robert D.

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AB - During the last several years, the mechanism of IFNγ-dependent signal transduction has been the focus of intense investigation. This research has recently culminated in the elucidation of a comprehensive molecular understanding of the events that underlie IFNγ-induced cellular responses. The structure and function of the IFNγ receptor have been defined. The mechanism of IFNγ signal transduction has been largely elucidated, and the physiologic relevance of this process validated. Most recently, the molecular events that link receptor ligation to signal transduction have been established. Together these insights have produced a model of IFNγ signaling that is nearly complete and that serves as a paradigm for signaling by other members of the cytokine receptor superfamily.

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KW - Stat1

KW - signal transduction

KW - transcription factors

KW - tyrosine kinases

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JO - Annual Review of Immunology

JF - Annual Review of Immunology

ER -

The IFNγ receptor: A paradigm for cytokine receptor signaling

Abstract

Keywords

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